Understanding the effect of controlling phosphorothioate chirality in the DNA gap on the potency and safety of gapmer antisense oligonucleotides.

Østergaard, Michael E; De Hoyos, Cheryl L; Wan, W Brad; Shen, Wen; Low, Audrey; Berdeja, Andres; Vasquez, Guillermo; Murray, Susan; Migawa, Michael T; Liang, Xue-Hai; Swayze, Eric E; Crooke, Stanley T; Seth, Punit P

Østergaard, Michael E; De Hoyos, Cheryl L; Wan, W Brad; Shen, Wen; Low, Audrey; Berdeja, Andres; Vasquez, Guillermo; Murray, Susan; Migawa, Michael T; Liang, Xue-Hai; Swayze, Eric E; Crooke, Stanley T; Seth, Punit P.

Afiliação

Østergaard ME; Ionis Pharmaceuticals Inc., 2855 Gazelle Court, Carlsbad, CA 92010, USA.
De Hoyos CL; Ionis Pharmaceuticals Inc., 2855 Gazelle Court, Carlsbad, CA 92010, USA.
Wan WB; Ionis Pharmaceuticals Inc., 2855 Gazelle Court, Carlsbad, CA 92010, USA.
Shen W; Ionis Pharmaceuticals Inc., 2855 Gazelle Court, Carlsbad, CA 92010, USA.
Low A; Ionis Pharmaceuticals Inc., 2855 Gazelle Court, Carlsbad, CA 92010, USA.
Berdeja A; Ionis Pharmaceuticals Inc., 2855 Gazelle Court, Carlsbad, CA 92010, USA.
Vasquez G; Ionis Pharmaceuticals Inc., 2855 Gazelle Court, Carlsbad, CA 92010, USA.
Murray S; Ionis Pharmaceuticals Inc., 2855 Gazelle Court, Carlsbad, CA 92010, USA.
Migawa MT; Ionis Pharmaceuticals Inc., 2855 Gazelle Court, Carlsbad, CA 92010, USA.
Liang XH; Ionis Pharmaceuticals Inc., 2855 Gazelle Court, Carlsbad, CA 92010, USA.
Swayze EE; Ionis Pharmaceuticals Inc., 2855 Gazelle Court, Carlsbad, CA 92010, USA.
Crooke ST; Ionis Pharmaceuticals Inc., 2855 Gazelle Court, Carlsbad, CA 92010, USA.
Seth PP; Ionis Pharmaceuticals Inc., 2855 Gazelle Court, Carlsbad, CA 92010, USA.

Nucleic Acids Res ; 48(4): 1691-1700, 2020 02 28.

Article em En | MEDLINE | ID: mdl-31980820

Assuntos

DNA/genética; Oligonucleotídeos Antissenso/genética; Oligonucleotídeos Fosforotioatos/genética; Ribonuclease H/genética; Animais; DNA/química; Camundongos; Oligonucleotídeos Antissenso/química; Oligonucleotídeos Fosforotioatos/química; Ligação Proteica/genética; Ribonuclease H/química

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: DNA / Oligonucleotídeos Antissenso / Ribonuclease H / Oligonucleotídeos Fosforotioatos Limite: Animals Idioma: En Ano de publicação: 2020 Tipo de documento: Article

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