Your browser doesn't support javascript.
loading
Combining an in silico proarrhythmic risk assay with a tPKPD model to predict QTc interval prolongation in the anesthetized guinea pig assay.
Morissette, Pierre; Polak, Sebastian; Chain, Anne; Zhai, Jin; Imredy, John P; Wildey, Mary Jo; Travis, Jeffrey; Fitzgerald, Kevin; Fanelli, Patrick; Passini, Elisa; Rodriguez, Blanca; Sannajust, Frederick; Regan, Christopher.
Afiliação
  • Morissette P; Safety Assessment & Laboratory Animal Resources (SALAR), Merck & Co., Inc., West Point, PA, USA. Electronic address: pierre_morissette@merck.com.
  • Polak S; Certara UK Limited, Simcyp Division, Sheffield, UK; Jagiellonian University Medical College, Faculty of Pharmacy, Krakow, Poland.
  • Chain A; Pharmacokinetics, Pharmacodynamics and Drug Metabolism (PPDM), Merck & Co., Inc., Rahway, NJ, USA.
  • Zhai J; Safety Assessment & Laboratory Animal Resources (SALAR), Merck & Co., Inc., West Point, PA, USA.
  • Imredy JP; Safety Assessment & Laboratory Animal Resources (SALAR), Merck & Co., Inc., West Point, PA, USA.
  • Wildey MJ; Pharmacology, Screening and Informatics, Merck & Co., Kenilworth, NJ, USA.
  • Travis J; Safety Assessment & Laboratory Animal Resources (SALAR), Merck & Co., Inc., West Point, PA, USA.
  • Fitzgerald K; Safety Assessment & Laboratory Animal Resources (SALAR), Merck & Co., Inc., West Point, PA, USA.
  • Fanelli P; Safety Assessment & Laboratory Animal Resources (SALAR), Merck & Co., Inc., West Point, PA, USA.
  • Passini E; Computational Cardiovascular Science Group, Department of Computer Science, BHF Centre of Research Excellence, University of Oxford, Oxford, UK.
  • Rodriguez B; Computational Cardiovascular Science Group, Department of Computer Science, BHF Centre of Research Excellence, University of Oxford, Oxford, UK.
  • Sannajust F; Safety Assessment & Laboratory Animal Resources (SALAR), Merck & Co., Inc., West Point, PA, USA.
  • Regan C; Safety Assessment & Laboratory Animal Resources (SALAR), Merck & Co., Inc., West Point, PA, USA.
Toxicol Appl Pharmacol ; 390: 114883, 2020 03 01.
Article em En | MEDLINE | ID: mdl-31981640
Assuntos
Palavras-chave
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Arritmias Cardíacas / Simulação por Computador / Técnicas Eletrofisiológicas Cardíacas / Antiarrítmicos / Modelos Biológicos Tipo de estudo: Etiology_studies / Prognostic_studies / Risk_factors_studies Limite: Animals / Humans Idioma: En Ano de publicação: 2020 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Arritmias Cardíacas / Simulação por Computador / Técnicas Eletrofisiológicas Cardíacas / Antiarrítmicos / Modelos Biológicos Tipo de estudo: Etiology_studies / Prognostic_studies / Risk_factors_studies Limite: Animals / Humans Idioma: En Ano de publicação: 2020 Tipo de documento: Article