Facile nose-to-brain delivery of rotigotine-loaded polymer micelles thermosensitive hydrogels: In vitro characterization and in vivo behavior study.

Wang, Fangyuan; Yang, Zhuanzhuan; Liu, Mengli; Tao, Yaotian; Li, Zhenbao; Wu, Zonghao; Gui, Shuangying

Wang, Fangyuan; Yang, Zhuanzhuan; Liu, Mengli; Tao, Yaotian; Li, Zhenbao; Wu, Zonghao; Gui, Shuangying.

Afiliação

Wang F; Department of Pharmaceutics, College of Pharmacy, Anhui University of Chinese Medicine, Hefei, China.
Yang Z; Department of Pharmaceutics, College of Pharmacy, Anhui University of Chinese Medicine, Hefei, China.
Liu M; Department of Pharmaceutics, College of Pharmacy, Anhui University of Chinese Medicine, Hefei, China.
Tao Y; Department of Pharmaceutics, College of Pharmacy, Anhui University of Chinese Medicine, Hefei, China; Institute of Pharmaceutics, Anhui Academy of Chinese Medicine, Hefei, China; Engineering Technology Research Center of Modernized Pharmaceutics, AnHui Province, China.
Li Z; Department of Pharmaceutics, College of Pharmacy, Anhui University of Chinese Medicine, Hefei, China; Institute of Pharmaceutics, Anhui Academy of Chinese Medicine, Hefei, China; Engineering Technology Research Center of Modernized Pharmaceutics, AnHui Province, China.
Wu Z; Hefei Huafang Pharmaceutical Science & Technology Co., Ltd., Hefei 230088, China.
Gui S; Department of Pharmaceutics, College of Pharmacy, Anhui University of Chinese Medicine, Hefei, China; Institute of Pharmaceutics, Anhui Academy of Chinese Medicine, Hefei, China; Engineering Technology Research Center of Modernized Pharmaceutics, AnHui Province, China. Electronic address: guishy0520

Int J Pharm ; 577: 119046, 2020 Mar 15.

Article em En | MEDLINE | ID: mdl-31982559

Assuntos

Agonistas de Dopamina/administração & dosagem; Sistemas de Liberação de Medicamentos; Polímeros/química; Tetra-Hidronaftalenos/administração & dosagem; Tiofenos/administração & dosagem; Administração Intranasal; Animais; Encéfalo/metabolismo; Agonistas de Dopamina/farmacocinética; Portadores de Fármacos/química; Feminino; Hidrogéis; Masculino; Micelas; Tamanho da Partícula; Coelhos; Ratos; Ratos Sprague-Dawley; Solubilidade; Temperatura; Tetra-Hidronaftalenos/farmacocinética; Tiofenos/farmacocinética

Palavras-chave

Brain targeting; Nasal delivery system; Polymeric micelles; Rotigotine; Thermosensitive gels

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Polímeros / Tetra-Hidronaftalenos / Tiofenos / Sistemas de Liberação de Medicamentos / Agonistas de Dopamina Limite: Animals Idioma: En Ano de publicação: 2020 Tipo de documento: Article

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