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Identification of a 2,4-diaminopyrimidine scaffold targeting Trypanosoma brucei pteridine reductase 1 from the LIBRA compound library screening campaign.
Linciano, Pasquale; Cullia, Gregorio; Borsari, Chiara; Santucci, Matteo; Ferrari, Stefania; Witt, Gesa; Gul, Sheraz; Kuzikov, Maria; Ellinger, Bernhard; Santarém, Nuno; Cordeiro da Silva, Anabela; Conti, Paola; Bolognesi, Maria Laura; Roberti, Marinella; Prati, Federica; Bartoccini, Francesca; Retini, Michele; Piersanti, Giovanni; Cavalli, Andrea; Goldoni, Luca; Bertozzi, Sine Mandrup; Bertozzi, Fabio; Brambilla, Enzo; Rizzo, Vincenzo; Piomelli, Daniele; Pinto, Andrea; Bandiera, Tiziano; Costi, Maria Paola.
Afiliação
  • Linciano P; Department of Life Sciences, University of Modena and Reggio Emilia, Via Campi 103, 41125, Modena, Italy.
  • Cullia G; Department of Pharmaceutical Sciences, University of Milan, Via Mangiagalli 25, 20133, Milan, Italy.
  • Borsari C; Department of Life Sciences, University of Modena and Reggio Emilia, Via Campi 103, 41125, Modena, Italy.
  • Santucci M; Department of Life Sciences, University of Modena and Reggio Emilia, Via Campi 103, 41125, Modena, Italy.
  • Ferrari S; Department of Life Sciences, University of Modena and Reggio Emilia, Via Campi 103, 41125, Modena, Italy.
  • Witt G; Fraunhofer Institute for Molecular Biology and Applied Ecology - ScreeningPort, Hamburg, Germany.
  • Gul S; Fraunhofer Institute for Molecular Biology and Applied Ecology - ScreeningPort, Hamburg, Germany.
  • Kuzikov M; Fraunhofer Institute for Molecular Biology and Applied Ecology - ScreeningPort, Hamburg, Germany.
  • Ellinger B; Fraunhofer Institute for Molecular Biology and Applied Ecology - ScreeningPort, Hamburg, Germany.
  • Santarém N; Institute for Molecular and Cell Biology, 4150-180 Porto, Portugal and Instituto de Investigação e Inovação Em Saúde, Universidade Do Porto, 4150-180, Porto, Portugal.
  • Cordeiro da Silva A; Institute for Molecular and Cell Biology, 4150-180 Porto, Portugal and Instituto de Investigação e Inovação Em Saúde, Universidade Do Porto, 4150-180, Porto, Portugal; Department of Biological Sciences, Faculty of Pharmacy, University of Porto, Portugal.
  • Conti P; Department of Pharmaceutical Sciences, University of Milan, Via Mangiagalli 25, 20133, Milan, Italy.
  • Bolognesi ML; Department of Pharmacy and Biotechnology, Alma Mater Studiorum-University of Bologna, Via Belmeloro 6, I-40126, Bologna, Italy.
  • Roberti M; Department of Pharmacy and Biotechnology, Alma Mater Studiorum-University of Bologna, Via Belmeloro 6, I-40126, Bologna, Italy.
  • Prati F; Department of Pharmacy and Biotechnology, Alma Mater Studiorum-University of Bologna, Via Belmeloro 6, I-40126, Bologna, Italy.
  • Bartoccini F; Computational and Chemical Biology, Istituto Italiano di Tecnologia, Via Morego 30, I-16163, Genova, Italy.
  • Retini M; Department of Biomolecular Sciences, Section of Chemistry, University of Urbino "Carlo Bo", Piazza Rinascimento 6, 61029, Urbino, Italy.
  • Piersanti G; Department of Biomolecular Sciences, Section of Chemistry, University of Urbino "Carlo Bo", Piazza Rinascimento 6, 61029, Urbino, Italy.
  • Cavalli A; Department of Pharmacy and Biotechnology, Alma Mater Studiorum-University of Bologna, Via Belmeloro 6, I-40126, Bologna, Italy; Computational and Chemical Biology, Istituto Italiano di Tecnologia, Via Morego 30, I-16163, Genova, Italy.
  • Goldoni L; Analytical Chemistry Lab, Istituto Italiano di Tecnologia, Via Morego 30, I-16163, Genova, Italy.
  • Bertozzi SM; Analytical Chemistry Lab, Istituto Italiano di Tecnologia, Via Morego 30, I-16163, Genova, Italy.
  • Bertozzi F; PharmaChemistry Line, Istituto Italiano di Tecnologia, Via Morego 30, I-16163, Genova, Italy.
  • Brambilla E; PharmaChemistry Line, Istituto Italiano di Tecnologia, Via Morego 30, I-16163, Genova, Italy.
  • Rizzo V; PharmaChemistry Line, Istituto Italiano di Tecnologia, Via Morego 30, I-16163, Genova, Italy.
  • Piomelli D; Departments of Anatomy and Neurobiology, Pharmacology and Biological Chemistry, University of California, Irvine, 92697-4625, USA.
  • Pinto A; Department of Food, Environmental and Nutritional Sciences, University of Milan, Via Celoria 2, 20133, Milan, Italy.
  • Bandiera T; PharmaChemistry Line, Istituto Italiano di Tecnologia, Via Morego 30, I-16163, Genova, Italy.
  • Costi MP; Department of Life Sciences, University of Modena and Reggio Emilia, Via Campi 103, 41125, Modena, Italy. Electronic address: mariapaola.costi@unimore.it.
Eur J Med Chem ; 189: 112047, 2020 Mar 01.
Article em En | MEDLINE | ID: mdl-31982652
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Oxirredutases / Pirimidinas / Trypanosoma brucei brucei / Inibidores Enzimáticos / Ensaios de Triagem em Larga Escala / Macrófagos / Antineoplásicos Tipo de estudo: Diagnostic_studies / Screening_studies Limite: Humans Idioma: En Ano de publicação: 2020 Tipo de documento: Article
Texto completo
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XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Oxirredutases / Pirimidinas / Trypanosoma brucei brucei / Inibidores Enzimáticos / Ensaios de Triagem em Larga Escala / Macrófagos / Antineoplásicos Tipo de estudo: Diagnostic_studies / Screening_studies Limite: Humans Idioma: En Ano de publicação: 2020 Tipo de documento: Article