Ruthenium-Catalyzed Cross-Selective Asymmetric Oxidative Coupling of Arenols.
Org Lett
; 22(4): 1469-1474, 2020 Feb 21.
Article
em En
| MEDLINE
| ID: mdl-31984748
ABSTRACT
(Aqua)ruthenium(salen) complex 1c achieved good to high chemo- and enantioselective oxidative cross-coupling of arenols. The catalytic system can be used to selectively produce C1-symmetric bis(arenol)s from the combination of C3- and C7-substituted 2-naphthols or phenols even when there is no significant difference in oxidation potential between the cross-coupling partners. This unique cross-selectivity is dominated by steric rather than electronic effects of the arenols and can be controlled by chemoselective single-electron oxidation and oxidative carbon-carbon bond formation.
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MEDLINE
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En
Ano de publicação:
2020
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Article