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Ocular involvement in systemic lupus erythematosus patients: a paradigm shift based on the experience of a tertiary referral center.
Dias-Santos, A; Tavares Ferreira, J; Pinheiro, S; Cunha, J P; Alves, M; Papoila, A L; Moraes-Fontes, M Francisca; Proença, R.
Afiliação
  • Dias-Santos A; Department of Ophthalmology, Centro Hospitalar e Universitário de Lisboa Central, Lisbon, Portugal.
  • Tavares Ferreira J; Department of Ophthalmology, Hospital CUF Descobertas, Lisbon, Portugal.
  • Pinheiro S; NOVA Medical School, Universidade NOVA de Lisboa, Lisbon, Portugal.
  • Cunha JP; Department of Ophthalmology, Centro Hospitalar e Universitário de Lisboa Central, Lisbon, Portugal.
  • Alves M; Department of Ophthalmology, Hospital CUF Descobertas, Lisbon, Portugal.
  • Papoila AL; NOVA Medical School, Universidade NOVA de Lisboa, Lisbon, Portugal.
  • Moraes-Fontes MF; Autoimmune Disease Unit, Unidade de Doenças Auto-imunes/Serviço Medicina 3, Hospital de Santo António dos Capuchos, Centro Hospitalar e Universitário de Lisboa Central, Lisbon, Portugal.
  • Proença R; Department of Ophthalmology, Centro Hospitalar e Universitário de Lisboa Central, Lisbon, Portugal.
Lupus ; 29(3): 283-289, 2020 Mar.
Article em En | MEDLINE | ID: mdl-31992127
ABSTRACT

OBJECTIVE:

To evaluate ocular involvement in a cohort of systemic lupus erythematosus (SLE) patients of a tertiary referral center and to compare the results with the existing literature.

METHODS:

Patients underwent a complete ophthalmological evaluation, including visual acuity, slit-lamp examination, fluorescein staining, Schirmer-I test, Goldmann applanation tonometry, fundoscopy, 10-2 automated threshold visual fields, fundus autofluorescence and spectral-domain optical coherence tomography to screen for hydroxychloroquine (HCQ) macular toxicity.

RESULTS:

A total of 161 patients (16 men and 145 women) were enrolled in this study. The mean age was 47.6 years and the mean disease duration was 11.5 years. Fifty patients (31.1%) had at least one ocular manifestation of SLE. The most frequent manifestation was dry eye syndrome (12.4%), immediately followed by cataracts (11.2%) and HCQ macular toxicity (11.2%). Among patients with HCQ maculopathy, two presented with an atypical spectral-domain optical coherence tomography pattern. Five patients (3.1%) presented with glaucoma, two patients (1.2%) presented with SLE retinopathy while only one presented with lupus choroidopathy (0.6%).

CONCLUSIONS:

Compared with previous studies, we conclude there has been a significant reduction in disease-related ocular complications, particularly those associated with poor systemic disease control. On the other hand, drug and age-related complications are assuming a prominent role in the ophthalmic care of these patients.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Oftalmopatias / Lúpus Eritematoso Sistêmico Tipo de estudo: Diagnostic_studies / Etiology_studies / Observational_studies / Prevalence_studies / Risk_factors_studies Limite: Adult / Female / Humans / Male / Middle aged Idioma: En Ano de publicação: 2020 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Oftalmopatias / Lúpus Eritematoso Sistêmico Tipo de estudo: Diagnostic_studies / Etiology_studies / Observational_studies / Prevalence_studies / Risk_factors_studies Limite: Adult / Female / Humans / Male / Middle aged Idioma: En Ano de publicação: 2020 Tipo de documento: Article