Characterization of the human GnRH neuron developmental transcriptome using a <i>GNRH1</i>-TdTomato reporter line in human pluripotent stem cells.

Lund, Carina; Yellapragada, Venkatram; Vuoristo, Sanna; Balboa, Diego; Trova, Sara; Allet, Cecile; Eskici, Nazli; Pulli, Kristiina; Giacobini, Paolo; Tuuri, Timo; Raivio, Taneli

Characterization of the human GnRH neuron developmental transcriptome using a GNRH1-TdTomato reporter line in human pluripotent stem cells.

Lund, Carina; Yellapragada, Venkatram; Vuoristo, Sanna; Balboa, Diego; Trova, Sara; Allet, Cecile; Eskici, Nazli; Pulli, Kristiina; Giacobini, Paolo; Tuuri, Timo; Raivio, Taneli.

Afiliação

Lund C; Stem Cells and Metabolism Research Program, Faculty of Medicine, 00014 University of Helsinki, Helsinki, Finland.
Yellapragada V; Medicum, Faculty of Medicine, 00014 University of Helsinki, Helsinki, Finland.
Vuoristo S; Stem Cells and Metabolism Research Program, Faculty of Medicine, 00014 University of Helsinki, Helsinki, Finland.
Balboa D; Medicum, Faculty of Medicine, 00014 University of Helsinki, Helsinki, Finland.
Trova S; Department of Obstetrics and Gynecology, 00029 Helsinki University Hospital, Helsinki, Finland.
Allet C; Centre for Genomic Regulation, The Barcelona Institute of Science and Technology, Dr. Aiguader 88, 08003 Barcelona, Spain.
Eskici N; Inserm, Laboratory of Development and Plasticity of the Neuroendocrine Brain, Jean-Pierre Aubert Research Center, U1172 Lille, France.
Pulli K; Inserm, Laboratory of Development and Plasticity of the Neuroendocrine Brain, Jean-Pierre Aubert Research Center, U1172 Lille, France.
Giacobini P; Stem Cells and Metabolism Research Program, Faculty of Medicine, 00014 University of Helsinki, Helsinki, Finland.
Tuuri T; Medicum, Faculty of Medicine, 00014 University of Helsinki, Helsinki, Finland.
Raivio T; Stem Cells and Metabolism Research Program, Faculty of Medicine, 00014 University of Helsinki, Helsinki, Finland.

Dis Model Mech ; 13(3)2020 03 13.

Article em En | MEDLINE | ID: mdl-31996360

Assuntos

Genes Reporter; Hormônio Liberador de Gonadotropina/metabolismo; Neurônios/metabolismo; Células-Tronco Pluripotentes/metabolismo; Transcriptoma/genética; Proteína 9 Associada à CRISPR/metabolismo; Sistemas CRISPR-Cas/genética; Linhagem Celular; Feto/citologia; Fator 8 de Crescimento de Fibroblasto/farmacologia; Humanos; Hipogonadismo/genética; Proteínas com Homeodomínio LIM/metabolismo; Neurônios/efeitos dos fármacos; Células-Tronco Pluripotentes/efeitos dos fármacos; RNA Mensageiro/genética; RNA Mensageiro/metabolismo; Fatores de Transcrição/metabolismo; Regulação para Cima/efeitos dos fármacos; Regulação para Cima/genética

Palavras-chave

GnRH neuron; Human; ISL1; Reporter; Transcriptome; hPSCs

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Hormônio Liberador de Gonadotropina / Genes Reporter / Células-Tronco Pluripotentes / Transcriptoma / Neurônios Tipo de estudo: Prognostic_studies Limite: Humans Idioma: En Ano de publicação: 2020 Tipo de documento: Article

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