Evaluation of serum lipid, lipoprotein, and apolipoprotein levels in psoriatic patients: a systematic review and meta-analysis of case-control studies.
Postepy Dermatol Alergol
; 36(6): 692-702, 2019 Dec.
Article
em En
| MEDLINE
| ID: mdl-31997997
ABSTRACT
INTRODUCTION:
Psoriasis is a T cell-mediated inflammatory skin disease in which fatty acids may be a link between psoriasis and its comorbidity.AIM:
The present meta-analysis aimed to evaluate lipid, lipoprotein, and apolipoprotein levels in the psoriatic patients compared with the control subjects. MATERIAL ANDMETHODS:
Four databases, including Web of Science, Scopus, PubMed, and Cochrane Library were searched until July 2017. All records analysed were case-control studies. The quality of the questionnaires was evaluated using the Newcastle-Ottawa Scale (NOS). A random-effects meta-analysis was done by Rev Man 5.3 using mean difference (MD) and 95% confidence intervals (CIs).RESULTS:
Out of 580 studies identified in four databases, 49 studies were included and analysed in this meta-analysis. The results showed that MD of total cholesterol, triglyceride, LDL, VLDL, HDL, Lp(a), Apo A1, and Apo B levels in the patients compared with the controls were (MD = 13.74 mg/dl; 95% CI 7.72-19.75; p< 0.00001), (MD = 26.04 mg/dl; 95% CI 20.77-31.31; p< 0.00001), (MD = 11.41 mg/dl; 95% CI 6.26-16.57; p< 0.0001), (MD = 4.82 mg/dl; 95% CI 3.63-6.00; p< 0.00001), (MD = -2.78 mg/dl; 95% CI -4.53 - -1.03; p< 0.002), (MD = 8.51 mg/dl; 95% CI 4.86-12.17; p< 0.0001), (MD = -6.60 mg/dl; 95% CI -13.96 - 0.75; p< 0.08), and (MD = 9.70 mg/dl; 95% CI 3.02-16.39; p< 0.004), respectively.CONCLUSIONS:
This meta-analysis identified abnormality of serum lipid, lipoprotein, and apolipoproteinprofiles in psoriatic patients compared with the controls as well as possibly a greater risk of atherosclerosis and cardiovascular (CV) accidents in the patients.
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Base de dados:
MEDLINE
Tipo de estudo:
Observational_studies
/
Risk_factors_studies
/
Systematic_reviews
Idioma:
En
Ano de publicação:
2019
Tipo de documento:
Article