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Physical activity and risks of breast and colorectal cancer: a Mendelian randomisation analysis.
Papadimitriou, Nikos; Dimou, Niki; Tsilidis, Konstantinos K; Banbury, Barbara; Martin, Richard M; Lewis, Sarah J; Kazmi, Nabila; Robinson, Timothy M; Albanes, Demetrius; Aleksandrova, Krasimira; Berndt, Sonja I; Timothy Bishop, D; Brenner, Hermann; Buchanan, Daniel D; Bueno-de-Mesquita, Bas; Campbell, Peter T; Castellví-Bel, Sergi; Chan, Andrew T; Chang-Claude, Jenny; Ellingjord-Dale, Merete; Figueiredo, Jane C; Gallinger, Steven J; Giles, Graham G; Giovannucci, Edward; Gruber, Stephen B; Gsur, Andrea; Hampe, Jochen; Hampel, Heather; Harlid, Sophia; Harrison, Tabitha A; Hoffmeister, Michael; Hopper, John L; Hsu, Li; María Huerta, José; Huyghe, Jeroen R; Jenkins, Mark A; Keku, Temitope O; Kühn, Tilman; La Vecchia, Carlo; Le Marchand, Loic; Li, Christopher I; Li, Li; Lindblom, Annika; Lindor, Noralane M; Lynch, Brigid; Markowitz, Sanford D; Masala, Giovanna; May, Anne M; Milne, Roger; Monninkhof, Evelyn.
Afiliação
  • Papadimitriou N; Section of Nutrition and Metabolism, International Agency for Research on Cancer, Lyon, France.
  • Dimou N; Section of Nutrition and Metabolism, International Agency for Research on Cancer, Lyon, France.
  • Tsilidis KK; Department of Hygiene and Epidemiology, University of Ioannina School of Medicine, Ioannina, Greece.
  • Banbury B; Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, UK.
  • Martin RM; Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.
  • Lewis SJ; MRC Integrative Epidemiology Unit (IEU), Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, UK.
  • Kazmi N; Bristol Medical School, Department of Population Health Sciences, University of Bristol, Bristol, UK.
  • Robinson TM; National Institute for Health Research (NIHR) Bristol Biomedical Research Centre, University Hospitals Bristol NHS Foundation Trust and the University of Bristol, Bristol, UK.
  • Albanes D; Bristol Medical School, Department of Population Health Sciences, University of Bristol, Bristol, UK.
  • Aleksandrova K; MRC Integrative Epidemiology Unit (IEU), Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, UK.
  • Berndt SI; Bristol Medical School, Department of Population Health Sciences, University of Bristol, Bristol, UK.
  • Timothy Bishop D; Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MA, USA.
  • Brenner H; German Institute of Human Nutrition Potsdam-Rehbruecke (DIfE), Arthur-Scheunert-Allee 114-116, 14558, Nuthetal, Germany.
  • Buchanan DD; Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MA, USA.
  • Bueno-de-Mesquita B; Leeds Institute of Cancer and Pathology, University of Leeds, Leeds, UK.
  • Campbell PT; Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg, Germany.
  • Castellví-Bel S; Division of Preventive Oncology, German Cancer Research Center (DKFZ) and National Center for Tumor Diseases (NCT), Heidelberg, Germany.
  • Chan AT; German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany.
  • Chang-Claude J; Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Melbourne, VIC, Australia.
  • Ellingjord-Dale M; Colorectal Oncogenomics Group, Genetic Epidemiology Laboratory, Department of Pathology, The University of Melbourne, Parkville, VIC, Australia.
  • Figueiredo JC; Genetic Medicine and Family Cancer Clinic, The Royal Melbourne Hospital, Parkville, VIC, Australia.
  • Gallinger SJ; Former senior scientist, Dept. for Determinants of Chronic Diseases (DCD), National Institute for Public Health and the Environment (RIVM), PO Box 1, 3720 BA, Bilthoven, Netherlands.
  • Giles GG; Former associate professor, Department of Gastroenterology and Hepatology, University Medical Centre, Utrecht, Netherlands.
  • Giovannucci E; Former visiting professor, Dept. of Epidemiology and Biostatistics, The School of Public Health, Imperial College London, St Mary's Campus, Norfolk Place, London, W2 1PG, London, UK.
  • Gruber SB; Former academic Icon / visiting professor, Dept. of Social & Preventive Medicine, Faculty of Medicine, University of Malaya, Pantai Valley, 50603, Kuala Lumpur, Malaysia.
  • Gsur A; Behavioral and Epidemiology Research Group, American Cancer Society, Atlanta, GA, USA.
  • Hampe J; Gastroenterology Department, Hospital Clínic, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBEREHD), University of Barcelona, Barcelona, Spain.
  • Hampel H; Division of Gastroenterology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.
  • Harlid S; Clinical and Translational Epidemiology Unit, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.
  • Harrison TA; Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany.
  • Hoffmeister M; University Medical Centre Hamburg-Eppendorf, University Cancer Centre Hamburg (UCCH), Hamburg, Germany.
  • Hopper JL; Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, UK.
  • Hsu L; Department of Medicine, Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, CA, USA.
  • María Huerta J; Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
  • Huyghe JR; Lunenfeld Tanenbaum Research Institute, Mount Sinai Hospital, University of Toronto, Toronto, ON, Canada.
  • Jenkins MA; Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Melbourne, VIC, Australia.
  • Keku TO; Cancer Epidemiology and Intelligence Division, Cancer Council Victoria, Melbourne, VIC, Australia.
  • Kühn T; Department of Epidemiology, Harvard T.H. Chan School of Public Health, Harvard University, Boston, MA, USA.
  • La Vecchia C; Department of Nutrition, T.H. H, Chan School of Public Health, Boston, MA, USA.
  • Le Marchand L; Channing Division of Network Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.
  • Li CI; Department of Preventive Medicine, USC Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
  • Li L; Institute of Cancer Research, Department of Medicine I, Medical University Vienna, Vienna, Austria.
  • Lindblom A; Department of Medicine I, University Hospital Dresden, Technische Universität Dresden (TU Dresden), Dresden, Germany.
  • Lindor NM; Division of Human Genetics, Department of Internal Medicine, The Ohio State University Comprehensive Cancer Center, Columbus, OH, USA.
  • Lynch B; Department of Radiation Sciences, Oncology, Umea University, 901 87, Umea, Sweden.
  • Markowitz SD; Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.
  • Masala G; Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg, Germany.
  • May AM; Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Melbourne, VIC, Australia.
  • Milne R; Department of Epidemiology, School of Public Health and Institute of Health and Environment, Seoul National University, Seoul, South Korea.
  • Monninkhof E; Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.
Nat Commun ; 11(1): 597, 2020 01 30.
Article em En | MEDLINE | ID: mdl-32001714
ABSTRACT
Physical activity has been associated with lower risks of breast and colorectal cancer in epidemiological studies; however, it is unknown if these associations are causal or confounded. In two-sample Mendelian randomisation analyses, using summary genetic data from the UK Biobank and GWA consortia, we found that a one standard deviation increment in average acceleration was associated with lower risks of breast cancer (odds ratio [OR] 0.51, 95% confidence interval [CI] 0.27 to 0.98, P-value = 0.04) and colorectal cancer (OR 0.66, 95% CI 0.48 to 0.90, P-value = 0.01). We found similar magnitude inverse associations for estrogen positive (ER+ve) breast cancer and for colon cancer. Our results support a potentially causal relationship between higher physical activity levels and lower risks of breast cancer and colorectal cancer. Based on these data, the promotion of physical activity is probably an effective strategy in the primary prevention of these commonly diagnosed cancers.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Neoplasias da Mama / Neoplasias Colorretais / Exercício Físico / Predisposição Genética para Doença / Análise da Randomização Mendeliana Tipo de estudo: Clinical_trials / Etiology_studies / Risk_factors_studies Limite: Female / Humans Idioma: En Ano de publicação: 2020 Tipo de documento: Article
Texto completo
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PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Neoplasias da Mama / Neoplasias Colorretais / Exercício Físico / Predisposição Genética para Doença / Análise da Randomização Mendeliana Tipo de estudo: Clinical_trials / Etiology_studies / Risk_factors_studies Limite: Female / Humans Idioma: En Ano de publicação: 2020 Tipo de documento: Article