Siglec1 enhances inflammation through miR-1260-dependent degradation of I&#954;B&#945; in COPD.

Li, Sensen; Jiang, Longfeng; Yang, Yanbing; Cao, Juan; Zhang, Qi; Zhang, Jinghai; Wang, Rui; Deng, Xiaozhao; Li, Yaojun

Siglec1 enhances inflammation through miR-1260-dependent degradation of IκBα in COPD.

Li, Sensen; Jiang, Longfeng; Yang, Yanbing; Cao, Juan; Zhang, Qi; Zhang, Jinghai; Wang, Rui; Deng, Xiaozhao; Li, Yaojun.

Afiliação

Li S; School of Life Science and Technology, China Pharmaceutical University, Nanjing 210009, Jiangsu, China; Department of Pharmacy, Luohe Central Hospital, Luohe 462000, Henan, China.
Jiang L; Department of Infectious Diseases, The First Affiliated Hospital with Nanjing Medical University, Nanjing 210002, Jiangsu, China.
Yang Y; Department of Respiratory Medicine, Luohe Central Hospital, Luohe 462000, Henan, China.
Cao J; Department of Respiratory Medicine, Luohe Central Hospital, Luohe 462000, Henan, China.
Zhang Q; Huadong Research Institute for Medicine and Biotechnics, Nanjing 210002, Jiangsu, China.
Zhang J; Huadong Research Institute for Medicine and Biotechnics, Nanjing 210002, Jiangsu, China.
Wang R; Department of Pharmacy, Luohe Central Hospital, Luohe 462000, Henan, China.
Deng X; School of Life Science and Technology, China Pharmaceutical University, Nanjing 210009, Jiangsu, China; Huadong Research Institute for Medicine and Biotechnics, Nanjing 210002, Jiangsu, China. Electronic address: xiaozhaodeng2014@163.com.
Li Y; Department of Respiratory Medicine, Luohe Central Hospital, Luohe 462000, Henan, China. Electronic address: liyaojun186@163.com.

Exp Mol Pathol ; 113: 104398, 2020 04.

Article em En | MEDLINE | ID: mdl-32007531

Assuntos

Inflamação/genética; MicroRNAs/metabolismo; Inibidor de NF-kappaB alfa/metabolismo; Proteólise; Doença Pulmonar Obstrutiva Crônica/genética; Lectina 1 Semelhante a Ig de Ligação ao Ácido Siálico/metabolismo; Regiões 3' não Traduzidas/genética; Animais; Linhagem Celular; Citocinas/metabolismo; Modelos Animais de Doenças; Regulação para Baixo/genética; Pulmão/metabolismo; Pulmão/patologia; Masculino; MicroRNAs/genética; Ligação Proteica; RNA Mensageiro/genética; RNA Mensageiro/metabolismo; Ratos; Ratos Sprague-Dawley

Palavras-chave

Chronic obstructive pulmonary disease; Inflammation; Nuclear factor of κ light polypeptide gene enhancer in B-cells inhibitor α; Sialic acid-binding Ig-like lectin 1; miR-1260

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Doença Pulmonar Obstrutiva Crônica / MicroRNAs / Proteólise / Lectina 1 Semelhante a Ig de Ligação ao Ácido Siálico / Inibidor de NF-kappaB alfa / Inflamação Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Ano de publicação: 2020 Tipo de documento: Article

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