Iron-induced derangement in hepatic &#916;-5 and &#916;-6 desaturation capacity and fatty acid profile leading to steatosis: Impact on extrahepatic tissues and prevention by antioxidant-rich extra virgin olive oil.

Barrera, Cynthia; Valenzuela, Rodrigo; Rincón, Miguel A; Espinosa, Alejandra; López-Arana, Sandra; González-Mañan, Daniel; Romero, Nalda; Vargas, Romina; Videla, Luis A

Iron-induced derangement in hepatic Δ-5 and Δ-6 desaturation capacity and fatty acid profile leading to steatosis: Impact on extrahepatic tissues and prevention by antioxidant-rich extra virgin olive oil.

Barrera, Cynthia; Valenzuela, Rodrigo; Rincón, Miguel A; Espinosa, Alejandra; López-Arana, Sandra; González-Mañan, Daniel; Romero, Nalda; Vargas, Romina; Videla, Luis A.

Afiliação

Barrera C; Department of Nutrition, Faculty of Medicine, University of Chile, Independencia 1027, Casilla, Santiago 70000, Chile.
Valenzuela R; Department of Nutrition, Faculty of Medicine, University of Chile, Independencia 1027, Casilla, Santiago 70000, Chile. Electronic address: rvalenzuelab@med.uchile.cl.
Rincón MA; Institute of Nutrition and Food Technology, University of Chile, Santiago, Chile.
Espinosa A; Department of Medical Technology, Faculty of Medicine, University of Chile, Santiago, Chile.
López-Arana S; Department of Nutrition, Faculty of Medicine, University of Chile, Independencia 1027, Casilla, Santiago 70000, Chile.
González-Mañan D; Núcleo de Química y Bioquímica, Facultad de Ciencias, Universidad Mayor, Chile.
Romero N; Department of Food Science and Chemical Technology, Faculty of Chemical Sciences and Pharmacy, University of Chile, Santiago, Chile.
Vargas R; Molecular and Clinical Pharmacology Program, Institute of Biomedical Sciences, Faculty of Medicine, University of Chile, Santiago, Chile.
Videla LA; Molecular and Clinical Pharmacology Program, Institute of Biomedical Sciences, Faculty of Medicine, University of Chile, Santiago, Chile.

Prostaglandins Leukot Essent Fatty Acids ; 153: 102058, 2020 02.

Article em En | MEDLINE | ID: mdl-32007744

Assuntos

Antioxidantes/administração & dosagem; Ácidos Graxos Dessaturases/genética; Fígado Gorduroso/prevenção & controle; Ferro/efeitos adversos; Linoleoil-CoA Desaturase/genética; Azeite de Oliva/administração & dosagem; Animais; Antioxidantes/química; Antioxidantes/farmacologia; Cromatografia Gasosa; Dessaturase de Ácido Graxo Delta-5; Modelos Animais de Doenças; Ácidos Graxos/análise; Fígado Gorduroso/induzido quimicamente; Fígado Gorduroso/epidemiologia; Regulação Enzimológica da Expressão Gênica/efeitos dos fármacos; Masculino; Azeite de Oliva/química; Azeite de Oliva/farmacologia; Ratos; Ratos Wistar

Palavras-chave

Antioxidant-rich extra virgin olive oil; Iron; LCPUFAs; Liver steatosis; Δ5- and Δ6-desaturases

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Linoleoil-CoA Desaturase / Ácidos Graxos Dessaturases / Fígado Gorduroso / Azeite de Oliva / Ferro / Antioxidantes Limite: Animals Idioma: En Ano de publicação: 2020 Tipo de documento: Article

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