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Anti-thyroid antibodies and thyroid echo pattern at baseline as risk factors for thyroid dysfunction induced by anti-programmed cell death-1 antibodies: a prospective study.
Okada, Norio; Iwama, Shintaro; Okuji, Takayuki; Kobayashi, Tomoko; Yasuda, Yoshinori; Wada, Eri; Onoue, Takeshi; Goto, Motomitsu; Sugiyama, Mariko; Tsunekawa, Taku; Takagi, Hiroshi; Hagiwara, Daisuke; Ito, Yoshihiro; Suga, Hidetaka; Banno, Ryoichi; Hase, Tetsunari; Morise, Masahiro; Kanda, Mitsuro; Yokota, Kenji; Hashimoto, Naozumi; Ando, Masahiko; Fujimoto, Yasushi; Nagino, Masato; Kodera, Yasuhiro; Fujishiro, Mitsuhiro; Hibi, Hideharu; Sone, Michihiko; Kiyoi, Hitoshi; Gotoh, Momokazu; Ando, Yuichi; Akiyama, Masashi; Hasegawa, Yoshinori; Arima, Hiroshi.
Afiliação
  • Okada N; Department of Endocrinology and Diabetes, Nagoya University Graduate School of Medicine, Nagoya, Japan.
  • Iwama S; Department of Endocrinology and Diabetes, Nagoya University Graduate School of Medicine, Nagoya, Japan. siwama@med.nagoya-u.ac.jp.
  • Okuji T; Department of Endocrinology and Diabetes, Nagoya University Graduate School of Medicine, Nagoya, Japan.
  • Kobayashi T; Department of Endocrinology and Diabetes, Nagoya University Graduate School of Medicine, Nagoya, Japan.
  • Yasuda Y; Department of Endocrinology and Diabetes, Nagoya University Graduate School of Medicine, Nagoya, Japan.
  • Wada E; Department of Endocrinology and Diabetes, Nagoya University Graduate School of Medicine, Nagoya, Japan.
  • Onoue T; Department of Endocrinology and Diabetes, Nagoya University Graduate School of Medicine, Nagoya, Japan.
  • Goto M; Department of Endocrinology and Diabetes, Nagoya University Graduate School of Medicine, Nagoya, Japan.
  • Sugiyama M; Department of Endocrinology and Diabetes, Nagoya University Graduate School of Medicine, Nagoya, Japan.
  • Tsunekawa T; Department of Endocrinology and Diabetes, Nagoya University Graduate School of Medicine, Nagoya, Japan.
  • Takagi H; Department of Endocrinology and Diabetes, Nagoya University Graduate School of Medicine, Nagoya, Japan.
  • Hagiwara D; Department of Endocrinology and Diabetes, Nagoya University Graduate School of Medicine, Nagoya, Japan.
  • Ito Y; Department of Endocrinology and Diabetes, Nagoya University Graduate School of Medicine, Nagoya, Japan.
  • Suga H; Department of Endocrinology and Diabetes, Nagoya University Graduate School of Medicine, Nagoya, Japan.
  • Banno R; Department of Endocrinology and Diabetes, Nagoya University Graduate School of Medicine, Nagoya, Japan.
  • Hase T; Department of Respiratory Medicine, Nagoya University Graduate School of Medicine, Nagoya, Japan.
  • Morise M; Department of Respiratory Medicine, Nagoya University Graduate School of Medicine, Nagoya, Japan.
  • Kanda M; Department of Gastroenterological Surgery (Surgery II), Nagoya University Graduate School of Medicine, Nagoya, Japan.
  • Yokota K; Department of Dermatology, Nagoya University Graduate School of Medicine, Nagoya, Japan.
  • Hashimoto N; Department of Respiratory Medicine, Nagoya University Graduate School of Medicine, Nagoya, Japan.
  • Ando M; Center for Advanced Medicine and Clinical Research, Nagoya University Hospital, Nagoya, Japan.
  • Fujimoto Y; Department of Otorhinolaryngology, Nagoya University Graduate School of Medicine, Nagoya, Japan.
  • Nagino M; Division of Surgical Oncology, Department of Surgery, Nagoya University Graduate School of Medicine, Nagoya, Japan.
  • Kodera Y; Department of Gastroenterological Surgery (Surgery II), Nagoya University Graduate School of Medicine, Nagoya, Japan.
  • Fujishiro M; Department of Gastroenterology and Hepatology, Nagoya University Graduate School of Medicine, Nagoya, Japan.
  • Hibi H; Department of Oral and Maxillofacial Surgery, Nagoya University Graduate School of Medicine, Nagoya, Japan.
  • Sone M; Department of Otorhinolaryngology, Nagoya University Graduate School of Medicine, Nagoya, Japan.
  • Kiyoi H; Department of Hematology and Oncology, Nagoya University Graduate School of Medicine, Nagoya, Japan.
  • Gotoh M; Department of Urology, Nagoya University Graduate School of Medicine, Nagoya, Japan.
  • Ando Y; Department of Clinical Oncology and Chemotherapy, Nagoya University Hospital, Nagoya, Japan.
  • Akiyama M; Department of Dermatology, Nagoya University Graduate School of Medicine, Nagoya, Japan.
  • Hasegawa Y; Department of Respiratory Medicine, Nagoya University Graduate School of Medicine, Nagoya, Japan.
  • Arima H; Department of Endocrinology and Diabetes, Nagoya University Graduate School of Medicine, Nagoya, Japan.
Br J Cancer ; 122(6): 771-777, 2020 03.
Article em En | MEDLINE | ID: mdl-32009131
BACKGROUND: Anti-programmed cell death-1 (PD-1) antibodies can cause thyroid dysfunction. However, no predictive biomarkers enabling stratification of thyroid dysfunction risk have been identified. METHODS: A total of 209 patients treated with an anti-PD-1 antibody were evaluated for anti-thyroid antibodies at baseline and prospectively for thyroid function every 6 weeks for 24 weeks after treatment initiation, and then observed until the visits stopped. Thyroid ultrasonography was performed if the patient was positive for anti-thyroid antibodies at baseline. RESULTS: Of the 209 patients, 19 (9.1%) developed thyroid dysfunction (destructive thyroiditis or hypothyroidism). The cumulative incidence of thyroid dysfunction was significantly higher in patients who were positive vs. negative for anti-thyroid antibodies (15/44 [34.1%] vs. 4/165 [2.4%], p < 0.001). Forty-two patients positive for anti-thyroid antibodies at baseline were divided into two groups according to the presence of an irregular echo pattern. The cumulative incidence of thyroid dysfunction was significantly higher in those with an irregular vs. a regular echo pattern (13/23 [56.5%] vs. 1/19 [5.3%], p = 0.001). None of the patients developed thyroid dysfunction after the initial 24-week period. CONCLUSIONS: The risk of thyroid dysfunction induced by anti-PD-1 antibodies can be predicted by evaluation of anti-thyroid antibodies and the thyroid echo pattern at baseline. TRIAL REGISTRATION: UMIN000019024.
Assuntos

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Glândula Tireoide / Tireoidite / Ultrassonografia / Receptor de Morte Celular Programada 1 Tipo de estudo: Diagnostic_studies / Etiology_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Adult / Aged / Aged80 / Female / Humans / Male / Middle aged Idioma: En Ano de publicação: 2020 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Glândula Tireoide / Tireoidite / Ultrassonografia / Receptor de Morte Celular Programada 1 Tipo de estudo: Diagnostic_studies / Etiology_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Adult / Aged / Aged80 / Female / Humans / Male / Middle aged Idioma: En Ano de publicação: 2020 Tipo de documento: Article