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Synthesis, anti-oomycete activity, and SAR studies of paeonol derivatives.
Tian, Yue-E; Sun, Di; Han, Xiao-Xiao; Yang, Jin-Ming; Zhang, Song; Feng, Nan-Nan; Zhu, Li-Na; Xu, Zhong-Yuan; Che, Zhi-Ping; Liu, Sheng-Ming; Lin, Xiao-Min; Jiang, Jia; Chen, Gen-Qiang.
Afiliação
  • Tian YE; Laboratory of Pharmaceutical Design and Synthesis, Department of Plant Protection, College of Forestry, Henan University of Science and Technology, Luoyang 471023, China.
  • Sun D; Laboratory of Pharmaceutical Design and Synthesis, Department of Plant Protection, College of Forestry, Henan University of Science and Technology, Luoyang 471023, China.
  • Han XX; Laboratory of Pharmaceutical Design and Synthesis, Department of Plant Protection, College of Forestry, Henan University of Science and Technology, Luoyang 471023, China.
  • Yang JM; Laboratory of Pharmaceutical Design and Synthesis, Department of Plant Protection, College of Forestry, Henan University of Science and Technology, Luoyang 471023, China.
  • Zhang S; Laboratory of Pharmaceutical Design and Synthesis, Department of Plant Protection, College of Forestry, Henan University of Science and Technology, Luoyang 471023, China.
  • Feng NN; Laboratory of Pharmaceutical Design and Synthesis, Department of Plant Protection, College of Forestry, Henan University of Science and Technology, Luoyang 471023, China.
  • Zhu LN; Laboratory of Pharmaceutical Design and Synthesis, Department of Plant Protection, College of Forestry, Henan University of Science and Technology, Luoyang 471023, China.
  • Xu ZY; Laboratory of Pharmaceutical Design and Synthesis, Department of Plant Protection, College of Forestry, Henan University of Science and Technology, Luoyang 471023, China.
  • Che ZP; Laboratory of Pharmaceutical Design and Synthesis, Department of Plant Protection, College of Forestry, Henan University of Science and Technology, Luoyang 471023, China.
  • Liu SM; Laboratory of Pharmaceutical Design and Synthesis, Department of Plant Protection, College of Forestry, Henan University of Science and Technology, Luoyang 471023, China.
  • Lin XM; Laboratory of Pharmaceutical Design and Synthesis, Department of Plant Protection, College of Forestry, Henan University of Science and Technology, Luoyang 471023, China.
  • Jiang J; Laboratory of Pharmaceutical Design and Synthesis, Department of Plant Protection, College of Forestry, Henan University of Science and Technology, Luoyang 471023, China.
  • Chen GQ; Laboratory of Pharmaceutical Design and Synthesis, Department of Plant Protection, College of Forestry, Henan University of Science and Technology, Luoyang 471023, China.
J Asian Nat Prod Res ; 23(2): 138-149, 2021 Feb.
Article em En | MEDLINE | ID: mdl-32009450
ABSTRACT
Three series of sulfonate derivatives of paeonol were synthesized and screened in vitro for their anti-oomycete activity against P. capsici, respectively. Among all the compounds, 4m displayed the best promising and pronounced anti-oomycete activity against P. capsici than zoxamide, with the EC50 values of 24.51 and 26.87 mg/L, respectively. The results show that acetyl and 4-OCH3 are two necessary groups. The existence of these two sites is closely related to the anti-oomycete activity. Relatively speaking, hydroxyl group is well tolerated, and the results showed that after modification of hydroxyl group with sulfonyl, the anti-oomycete activity was significantly increased. [Formula see text].
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Acetofenonas Idioma: En Ano de publicação: 2021 Tipo de documento: Article
Texto completo
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Acetofenonas Idioma: En Ano de publicação: 2021 Tipo de documento: Article