Photoprotective Activity of Topsentin, A Bis(Indole) Alkaloid from the Marine Sponge Spongosorites genitrix, by Regulation of COX-2 and Mir-4485 Expression in UVB-Irradiated Human Keratinocyte Cells.

Hwang, Jiyoung; Kim, Donghwa; Park, Jae Sung; Park, Hyen Joo; Shin, Jongheon; Lee, Sang Kook

Hwang, Jiyoung; Kim, Donghwa; Park, Jae Sung; Park, Hyen Joo; Shin, Jongheon; Lee, Sang Kook.

Afiliação

Hwang J; College of Pharmacy, Natural Products Research Institute, Seoul National University, Seoul 151-742, Korea.
Kim D; College of Pharmacy, Natural Products Research Institute, Seoul National University, Seoul 151-742, Korea.
Park JS; College of Pharmacy, Natural Products Research Institute, Seoul National University, Seoul 151-742, Korea.
Park HJ; College of Pharmacy, Natural Products Research Institute, Seoul National University, Seoul 151-742, Korea.
Shin J; College of Pharmacy, Natural Products Research Institute, Seoul National University, Seoul 151-742, Korea.
Lee SK; College of Pharmacy, Natural Products Research Institute, Seoul National University, Seoul 151-742, Korea.

Mar Drugs ; 18(2)2020 Jan 29.

Article em En | MEDLINE | ID: mdl-32013063

Assuntos

Ciclo-Oxigenase 2/metabolismo; Imidazóis/farmacologia; Indóis/farmacologia; Poríferos; Protetores contra Radiação/farmacologia; Animais; Células Epidérmicas; Queratinócitos/efeitos dos fármacos; Estresse Oxidativo/efeitos dos fármacos; Transdução de Sinais/efeitos dos fármacos; Pele; Raios Ultravioleta

Palavras-chave

COX-2; Spongosorites genitrix; Topsentin; UVB; miR-4485; skin inflammation

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Poríferos / Protetores contra Radiação / Ciclo-Oxigenase 2 / Imidazóis / Indóis Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Ano de publicação: 2020 Tipo de documento: Article

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