Complementary functions for the Ran gradient during division.
Small GTPases
; 12(3): 177-187, 2021 05.
Article
em En
| MEDLINE
| ID: mdl-32013678
ABSTRACT
The Ran pathway has a well-described function in nucleocytoplasmic transport, where active Ran dissociates importin/karyopherin-bound cargo containing a nuclear localization signal (NLS) in the nucleus. As cells enter mitosis, the nuclear envelope breaks down and a gradient of active Ran forms where levels are highest near chromatin. This gradient plays a crucial role in regulating mitotic spindle assembly, where active Ran binds to and releases importins from NLS-containing spindle assembly factors. An emerging theme is that the Ran gradient also regulates the actomyosin cortex for processes including polar body extrusion during meiosis, and cytokinesis. For these events, active Ran could play an inhibitory role, where importin-binding may help promote or stabilize a conformation or interaction that favours the recruitment and function of cortical regulators. For either spindle assembly or cortical polarity, the gradient of active Ran determines the extent of importin-binding, the effects of which could vary for different proteins.
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Texto completo:
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Base de dados:
MEDLINE
Assunto principal:
Núcleo Celular
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Sinais de Localização Nuclear
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Proteína ran de Ligação ao GTP
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Microtúbulos
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Mitose
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Fuso Acromático
Limite:
Animals
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Humans
Idioma:
En
Ano de publicação:
2021
Tipo de documento:
Article