Hypersusceptibility of Human Cytomegalovirus to Foscarnet Induced by Mutations in Helices K and P of the Viral DNA Polymerase.

Zarrouk, Karima; Pham, Van Dung; Piret, Jocelyne; Shi, Rong; Boivin, Guy

Zarrouk, Karima; Pham, Van Dung; Piret, Jocelyne; Shi, Rong; Boivin, Guy.

Afiliação

Zarrouk K; Research Center in Infectious Diseases, CHU de Québec-Laval University, Quebec City, Quebec, Canada.
Pham VD; Department of Biochemistry, Microbiology, and Bioinformatics, PROTEO, Laval University, Quebec City, Quebec, Canada.
Piret J; Institute of Integrative and Systems Biology, Laval University, Quebec City, Quebec, Canada.
Shi R; Research Center in Infectious Diseases, CHU de Québec-Laval University, Quebec City, Quebec, Canada.
Boivin G; Department of Biochemistry, Microbiology, and Bioinformatics, PROTEO, Laval University, Quebec City, Quebec, Canada.

Antimicrob Agents Chemother ; 64(4)2020 03 24.

Article em En | MEDLINE | ID: mdl-32015044

Assuntos

Antivirais/farmacologia; Citomegalovirus/efeitos dos fármacos; Citomegalovirus/genética; DNA Polimerase Dirigida por DNA/genética; Foscarnet/farmacologia; Infecções por Citomegalovirus/tratamento farmacológico; DNA Viral/genética; DNA Polimerase Dirigida por DNA/efeitos dos fármacos; Farmacorresistência Viral/genética; Humanos; Modelos Moleculares; Mutação

Palavras-chave

DNA polymerase; foscarnet; human cytomegalovirus; hypersusceptibility; molecular modeling; resistance

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Antivirais / Foscarnet / Citomegalovirus / DNA Polimerase Dirigida por DNA Limite: Humans Idioma: En Ano de publicação: 2020 Tipo de documento: Article

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