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Potent Zika and dengue cross-neutralizing antibodies induced by Zika vaccination in a dengue-experienced donor.
Dussupt, Vincent; Sankhala, Rajeshwer S; Gromowski, Gregory D; Donofrio, Gina; De La Barrera, Rafael A; Larocca, Rafael A; Zaky, Weam; Mendez-Rivera, Letzibeth; Choe, Misook; Davidson, Edgar; McCracken, Michael K; Brien, James D; Abbink, Peter; Bai, Hongjun; Bryan, Aubrey L; Bias, Candace Hope; Berry, Irina Maljkovic; Botero, Nubia; Cook, Tanya; Doria-Rose, Nicole A; Escuer, Ariadna Grinyo I; Frimpong, Justice Akuoku; Geretz, Aviva; Hernandez, Mayda; Hollidge, Bradley S; Jian, Ningbo; Kabra, Kareem; Leggat, David J; Liu, Jinyan; Pinto, Amelia K; Rutvisuttinunt, Wiriya; Setliff, Ian; Tran, Ursula; Townsley, Samantha; Doranz, Benjamin J; Rolland, Morgane; McDermott, Adrian B; Georgiev, Ivelin S; Thomas, Rasmi; Robb, Merlin L; Eckels, Kenneth H; Barranco, Elizabeth; Koren, Michael; Smith, Darci R; Jarman, Richard G; George, Sarah L; Stephenson, Kathryn E; Barouch, Dan H; Modjarrad, Kayvon; Michael, Nelson L.
Afiliação
  • Dussupt V; Emerging Infectious Diseases Branch, Center of Infectious Disease Research, Walter Reed Army Institute of Research, Silver Spring, MD, USA.
  • Sankhala RS; U.S. Military HIV Research Program, Center of Infectious Disease Research, Walter Reed Army Institute of Research, Silver Spring, MD, USA.
  • Gromowski GD; Henry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, MD, USA.
  • Donofrio G; Emerging Infectious Diseases Branch, Center of Infectious Disease Research, Walter Reed Army Institute of Research, Silver Spring, MD, USA.
  • De La Barrera RA; U.S. Military HIV Research Program, Center of Infectious Disease Research, Walter Reed Army Institute of Research, Silver Spring, MD, USA.
  • Larocca RA; Henry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, MD, USA.
  • Zaky W; Viral Diseases Branch, Center of Infectious Disease Research, Walter Reed Army Institute of Research, Silver Spring, MD, USA.
  • Mendez-Rivera L; Emerging Infectious Diseases Branch, Center of Infectious Disease Research, Walter Reed Army Institute of Research, Silver Spring, MD, USA.
  • Choe M; U.S. Military HIV Research Program, Center of Infectious Disease Research, Walter Reed Army Institute of Research, Silver Spring, MD, USA.
  • Davidson E; Henry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, MD, USA.
  • McCracken MK; Pilot Bioproduction Facility, Center for Enabling Capabilities, Walter Reed Army Institute of Research, Silver Spring, MD, USA.
  • Brien JD; Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA.
  • Abbink P; Ragon Institute of MGH, Cambridge, MA, USA.
  • Bai H; Emerging Infectious Diseases Branch, Center of Infectious Disease Research, Walter Reed Army Institute of Research, Silver Spring, MD, USA.
  • Bryan AL; U.S. Military HIV Research Program, Center of Infectious Disease Research, Walter Reed Army Institute of Research, Silver Spring, MD, USA.
  • Bias CH; Henry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, MD, USA.
  • Berry IM; Emerging Infectious Diseases Branch, Center of Infectious Disease Research, Walter Reed Army Institute of Research, Silver Spring, MD, USA.
  • Botero N; U.S. Military HIV Research Program, Center of Infectious Disease Research, Walter Reed Army Institute of Research, Silver Spring, MD, USA.
  • Cook T; Henry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, MD, USA.
  • Doria-Rose NA; Emerging Infectious Diseases Branch, Center of Infectious Disease Research, Walter Reed Army Institute of Research, Silver Spring, MD, USA.
  • Escuer AGI; U.S. Military HIV Research Program, Center of Infectious Disease Research, Walter Reed Army Institute of Research, Silver Spring, MD, USA.
  • Frimpong JA; Henry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, MD, USA.
  • Geretz A; Integral Molecular, Philadelphia, PA, USA.
  • Hernandez M; Viral Diseases Branch, Center of Infectious Disease Research, Walter Reed Army Institute of Research, Silver Spring, MD, USA.
  • Hollidge BS; Department of Molecular Microbiology and Immunology, Saint Louis University School of Medicine, Saint Louis, MO, USA.
  • Jian N; Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA.
  • Kabra K; Ragon Institute of MGH, Cambridge, MA, USA.
  • Leggat DJ; Emerging Infectious Diseases Branch, Center of Infectious Disease Research, Walter Reed Army Institute of Research, Silver Spring, MD, USA.
  • Liu J; U.S. Military HIV Research Program, Center of Infectious Disease Research, Walter Reed Army Institute of Research, Silver Spring, MD, USA.
  • Pinto AK; Henry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, MD, USA.
  • Rutvisuttinunt W; Integral Molecular, Philadelphia, PA, USA.
  • Setliff I; Pilot Bioproduction Facility, Center for Enabling Capabilities, Walter Reed Army Institute of Research, Silver Spring, MD, USA.
  • Tran U; Viral Diseases Branch, Center of Infectious Disease Research, Walter Reed Army Institute of Research, Silver Spring, MD, USA.
  • Townsley S; Pilot Bioproduction Facility, Center for Enabling Capabilities, Walter Reed Army Institute of Research, Silver Spring, MD, USA.
  • Doranz BJ; Pilot Bioproduction Facility, Center for Enabling Capabilities, Walter Reed Army Institute of Research, Silver Spring, MD, USA.
  • Rolland M; Vaccine Research Center, NIAID, NIH, Bethesda, MD, USA.
  • McDermott AB; Integral Molecular, Philadelphia, PA, USA.
  • Georgiev IS; U.S. Army Medical Research Institute of Infectious Diseases, Fort Detrick, MD, USA.
  • Thomas R; Emerging Infectious Diseases Branch, Center of Infectious Disease Research, Walter Reed Army Institute of Research, Silver Spring, MD, USA.
  • Robb ML; U.S. Military HIV Research Program, Center of Infectious Disease Research, Walter Reed Army Institute of Research, Silver Spring, MD, USA.
  • Eckels KH; Henry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, MD, USA.
  • Barranco E; Integral Molecular, Philadelphia, PA, USA.
  • Koren M; U.S. Army Medical Research Institute of Infectious Diseases, Fort Detrick, MD, USA.
  • Smith DR; Emerging Infectious Diseases Branch, Center of Infectious Disease Research, Walter Reed Army Institute of Research, Silver Spring, MD, USA.
  • Jarman RG; U.S. Military HIV Research Program, Center of Infectious Disease Research, Walter Reed Army Institute of Research, Silver Spring, MD, USA.
  • George SL; Henry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, MD, USA.
  • Stephenson KE; Pilot Bioproduction Facility, Center for Enabling Capabilities, Walter Reed Army Institute of Research, Silver Spring, MD, USA.
  • Barouch DH; Vaccine Research Center, NIAID, NIH, Bethesda, MD, USA.
  • Modjarrad K; Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA.
  • Michael NL; Ragon Institute of MGH, Cambridge, MA, USA.
Nat Med ; 26(2): 228-235, 2020 02.
Article em En | MEDLINE | ID: mdl-32015557
ABSTRACT
Zika virus (ZIKV) has caused significant disease, with widespread cases of neurological pathology and congenital neurologic defects. Rapid vaccine development has led to a number of candidates capable of eliciting potent ZIKV-neutralizing antibodies (reviewed in refs. 1-3). Despite advances in vaccine development, it remains unclear how ZIKV vaccination affects immune responses in humans with prior flavivirus immunity. Here we show that a single-dose immunization of ZIKV purified inactivated vaccine (ZPIV)4-7 in a dengue virus (DENV)-experienced human elicited potent cross-neutralizing antibodies to both ZIKV and DENV. Using a unique ZIKV virion-based sorting strategy, we isolated and characterized multiple antibodies, including one termed MZ4, which targets a novel site of vulnerability centered on the Envelope (E) domain I/III linker region and protects mice from viremia and viral dissemination following ZIKV or DENV-2 challenge. These data demonstrate that Zika vaccination in a DENV-experienced individual can boost pre-existing flavivirus immunity and elicit protective responses against both ZIKV and DENV. ZPIV vaccination in Puerto Rican individuals with prior flavivirus experience yielded similar cross-neutralizing potency after a single vaccination, highlighting the potential benefit of ZIKV vaccination in flavivirus-endemic areas.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Doadores de Tecidos / Vacinas Virais / Dengue / Infecção por Zika virus Limite: Animals / Female / Humans Idioma: En Ano de publicação: 2020 Tipo de documento: Article
Texto completo
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Doadores de Tecidos / Vacinas Virais / Dengue / Infecção por Zika virus Limite: Animals / Female / Humans Idioma: En Ano de publicação: 2020 Tipo de documento: Article