Folding control of a non-natural glycopeptide using saccharide-coded structural information for polypeptides.
Chem Commun (Camb)
; 56(18): 2767-2770, 2020 Mar 04.
Article
em En
| MEDLINE
| ID: mdl-32022009
ABSTRACT
We synthesized "glyco-arylopeptides", whose folding structure significantly changes depending on the kind of saccharide in their side chain. The saccharide moiety interacts with the main chain via hydrogen bonding, and the non-natural polypeptides form two well-defined architectures-(P)-31- and (M)-41-helices-depending on the length of the saccharide chains and even the configuration of a single stereo-genic center in the epimers.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Oligossacarídeos
/
Peptídeos
/
Glicopeptídeos
Idioma:
En
Ano de publicação:
2020
Tipo de documento:
Article