A micro-XRT image analysis and machine learning methodology for the characterisation of multi-particulate capsule formulations.
Int J Pharm X
; 2: 100041, 2020 Dec.
Article
em En
| MEDLINE
| ID: mdl-32025658
Abbreviation, Description; Classification model; Feature selection; IEV, Translation- and rotation-invariant cross-section; Machine learning; Micro-XRT particle analysis; OC-SVM, One-class support vector machine; OSH, Optimal separating hyperplane; Pharmaceutical formulation; RBF, Radial basis function; ROI, Region-of-interest; Sensitivity analysis; TC-SVM, Two-class support vector machine; V, Single pellet; V_CP, Pellet population; V_CP_Poros, Pellet population porosity; V_CP_ROI, Pellet population region-of-interest; V_CS, Capsule shell; V_CS_InV, Capsule shell internal volume; V_CS_Poros, Capsule shell void; V_CS_ROI, Capsule shell region-of-interest; V_ROI, Single pellet region-of-interest; Watershed image segmentation
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MEDLINE
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En
Ano de publicação:
2020
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Article