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Genomic characterization of Parengyodontium americanum sp. nov.
Teixeira, Marcus de M; Muszewska, Anna; Travis, Jason; Moreno, Leandro F; Ahmed, Sarah; Roe, Chandler; Mead, Heather; Steczkiewicz, Kamil; Lemmer, Darrin; de Hoog, Sybren; Keim, Paul; Wiederhold, Nathan; Barker, Bridget M.
Afiliação
  • Teixeira MM; Division of Pathogen Genomics, Translational Genomics Research Institute-North, Flagstaff, AZ, USA; Pathogen and Microbiome Institute, Northern Arizona University, Flagstaff, AZ, USA; Faculty of Medicine, University of Brasília, Brasília-DF, Brazil.
  • Muszewska A; Institute of Biochemistry and Biophysics, Polish Academy of Sciences, Warsaw, Poland.
  • Travis J; Division of Pathogen Genomics, Translational Genomics Research Institute-North, Flagstaff, AZ, USA.
  • Moreno LF; Westerdijk Fungal Biodiversity Institute, Utrecht, the Netherlands.
  • Ahmed S; Westerdijk Fungal Biodiversity Institute, Utrecht, the Netherlands.
  • Roe C; Division of Pathogen Genomics, Translational Genomics Research Institute-North, Flagstaff, AZ, USA; Pathogen and Microbiome Institute, Northern Arizona University, Flagstaff, AZ, USA.
  • Mead H; Pathogen and Microbiome Institute, Northern Arizona University, Flagstaff, AZ, USA.
  • Steczkiewicz K; Institute of Biochemistry and Biophysics, Polish Academy of Sciences, Warsaw, Poland; Centre of New Technologies, University of Warsaw, Warsaw, Poland. Electronic address: ksteczk@ibb.waw.pl.
  • Lemmer D; Division of Pathogen Genomics, Translational Genomics Research Institute-North, Flagstaff, AZ, USA.
  • de Hoog S; Westerdijk Fungal Biodiversity Institute, Utrecht, the Netherlands.
  • Keim P; Division of Pathogen Genomics, Translational Genomics Research Institute-North, Flagstaff, AZ, USA; Pathogen and Microbiome Institute, Northern Arizona University, Flagstaff, AZ, USA.
  • Wiederhold N; University of Texas Health Science Center at San Antonio, San Antonio, TX, USA.
  • Barker BM; Division of Pathogen Genomics, Translational Genomics Research Institute-North, Flagstaff, AZ, USA; Pathogen and Microbiome Institute, Northern Arizona University, Flagstaff, AZ, USA. Electronic address: bridget.barker@nau.edu.
Fungal Genet Biol ; 138: 103351, 2020 05.
Article em En | MEDLINE | ID: mdl-32028048
Modern genome analysis and phylogenomic methods have increased the number of fungal species, as well as enhanced appreciation of the degree of diversity within the fungal kingdom. In this context, we describe a new Parengyodontium species, P. americanum, which is phylogenetically related to the opportunistic human fungal pathogen P. album. Five unusual fungal isolates were recovered from five unique and confirmed coccidioidomycosis patients, and these isolates were subsequently submitted to detailed molecular and morphological identification procedures to determine identity. Molecular and morphological diagnostic analyses showed that the isolates belong to the Cordycipitaceae. Subsequently, three representative genomes were sequenced and annotated, and a new species, P. americanum, was identified. Using various genomic analyses, gene family expansions related to novel compounds and potential for ability to grow in diverse habitats are predicted. A general description of the genomic composition of this newly described species and comparison of genome content with Beauveria bassiana, Isaria fumosorosea and Cordyceps militaris shows a shared core genome of 6371 genes, and 148 genes that appear to be specific for P. americanum. This work provides the framework for future investigations of this interesting fungal species.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Coccidioidomicose / Hypocreales Limite: Humans Idioma: En Ano de publicação: 2020 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Coccidioidomicose / Hypocreales Limite: Humans Idioma: En Ano de publicação: 2020 Tipo de documento: Article