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Improvement in predicting drug sensitivity changes associated with protein mutations using a molecular dynamics based alchemical mutation method.
Ono, Fumie; Chiba, Shuntaro; Isaka, Yuta; Matsumoto, Shigeyuki; Ma, Biao; Katayama, Ryohei; Araki, Mitsugu; Okuno, Yasushi.
Afiliação
  • Ono F; Graduate School of Medicine, Kyoto University, 53 Shogoin-Kawaharacho, Sakyo-ku, Kyoto, Japan.
  • Chiba S; Medical Sciences Innovation Hub Program, RIKEN, 1-7-22, Suehiro-cho, Tsurumi-ku, Yokohama, Kanagawa, Japan.
  • Isaka Y; Research and Development Group for In Silico Drug Discovery, Center for Cluster Development and Coordination (CCD), Foundation for Biomedical Research and Innovation at Kobe (FBRI) 6-3-5, Minatojima-Minamimachi Chuo-ku, Kobe Japan, Hyogo, Japan.
  • Matsumoto S; Medical Sciences Innovation Hub Program, RIKEN, 1-7-22, Suehiro-cho, Tsurumi-ku, Yokohama, Kanagawa, Japan.
  • Ma B; Research and Development Group for In Silico Drug Discovery, Center for Cluster Development and Coordination (CCD), Foundation for Biomedical Research and Innovation at Kobe (FBRI) 6-3-5, Minatojima-Minamimachi Chuo-ku, Kobe Japan, Hyogo, Japan.
  • Katayama R; Division of Experimental Chemotherapy, Cancer Chemotherapy Center, Japanese Foundation for Cancer Research, Tokyo, Japan.
  • Araki M; Graduate School of Medicine, Kyoto University, 53 Shogoin-Kawaharacho, Sakyo-ku, Kyoto, Japan.
  • Okuno Y; Graduate School of Medicine, Kyoto University, 53 Shogoin-Kawaharacho, Sakyo-ku, Kyoto, Japan. okuno.yasushi.4c@kyoto-u.ac.jp.
Sci Rep ; 10(1): 2161, 2020 02 07.
Article em En | MEDLINE | ID: mdl-32034220
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Resistência a Medicamentos / Simulação de Acoplamento Molecular / Mutação Tipo de estudo: Diagnostic_studies / Guideline / Prognostic_studies / Risk_factors_studies Limite: Humans Idioma: En Ano de publicação: 2020 Tipo de documento: Article
Texto completo
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XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Resistência a Medicamentos / Simulação de Acoplamento Molecular / Mutação Tipo de estudo: Diagnostic_studies / Guideline / Prognostic_studies / Risk_factors_studies Limite: Humans Idioma: En Ano de publicação: 2020 Tipo de documento: Article