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Enhanced antitumor potential induced by chloroacetate-loaded benzophenones acting as fused tubulin-pyruvate dehydrogenase kinase 1 (PDHK1) ligands.
Ghinet, Alina; Thuru, Xavier; Floquet, Emilie; Dubois, Joëlle; Farce, Amaury; Rigo, Benoît.
Afiliação
  • Ghinet A; Yncréa Hauts-de-France, Hautes Etudes d'Ingénieur (HEI), UCLille, Health & Environment Department, Team Sustainable Chemistry, Laboratoire de Chimie Durable et Santé, 13 rue de Toul, F-59046 Lille, France; Univ. Lille, Inserm, CHU Lille, Institut Pasteur de Lille, U1167 - RID-AGE - Facteurs de r
  • Thuru X; Univ. Lille, CNRS, Inserm, CHU Lille, UMR9020 - UMR1277 - Canther - Cancer Heterogeneity, Plasticity and Resistance to Therapies, F-59000 Lille, France.
  • Floquet E; Univ. Lille, CNRS, Inserm, CHU Lille, UMR9020 - UMR1277 - Canther - Cancer Heterogeneity, Plasticity and Resistance to Therapies, F-59000 Lille, France; Plateau de Cytométrie, BioImaging Center Lille Nord de France, BICeL Campus Hospitalo-Universitaire, Lille, France.
  • Dubois J; Institut de Chimie des Substances Naturelles, UPR2301 CNRS, Centre de Recherche de Gif, Avenue de la Terrasse, F-91198 Gif-sur-Yvette Cedex, France.
  • Farce A; Université de Lille, Faculté des Sciences Pharmaceutiques et Biologiques, Rue du Pr Laguesse, B.P. 83, F-59006 Lille, France.
  • Rigo B; Yncréa Hauts-de-France, Hautes Etudes d'Ingénieur (HEI), UCLille, Health & Environment Department, Team Sustainable Chemistry, Laboratoire de Chimie Durable et Santé, 13 rue de Toul, F-59046 Lille, France; Univ. Lille, Inserm, CHU Lille, Institut Pasteur de Lille, U1167 - RID-AGE - Facteurs de r
Bioorg Chem ; 96: 103643, 2020 03.
Article em En | MEDLINE | ID: mdl-32035298
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Benzofenonas / Inibidores de Proteínas Quinases / Moduladores de Tubulina / Piruvato Desidrogenase Quinase de Transferência de Acetil / Acetatos / Antineoplásicos Limite: Humans Idioma: En Ano de publicação: 2020 Tipo de documento: Article
Texto completo
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XML
PubMed Links
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Benzofenonas / Inibidores de Proteínas Quinases / Moduladores de Tubulina / Piruvato Desidrogenase Quinase de Transferência de Acetil / Acetatos / Antineoplásicos Limite: Humans Idioma: En Ano de publicação: 2020 Tipo de documento: Article