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The minimal promoter (P1) of Xist is non-essential for X chromosome inactivation.
Yao, Bing; Liang, Mingming; Liu, Hongmei; Sui, Tingting; Song, Yuning; Zhang, Yuxin; Deng, Jichao; Xu, Yuxin; Lai, Liangxue; Li, Zhanjun.
Afiliação
  • Yao B; Key Laboratory of Zoonosis Research, Ministry of Education, College of Animal Science, Jilin University, Changchun, China.
  • Liang M; Key Laboratory of Zoonosis Research, Ministry of Education, College of Animal Science, Jilin University, Changchun, China.
  • Liu H; Key Laboratory of Zoonosis Research, Ministry of Education, College of Animal Science, Jilin University, Changchun, China.
  • Sui T; Key Laboratory of Zoonosis Research, Ministry of Education, College of Animal Science, Jilin University, Changchun, China.
  • Song Y; Key Laboratory of Zoonosis Research, Ministry of Education, College of Animal Science, Jilin University, Changchun, China.
  • Zhang Y; Key Laboratory of Zoonosis Research, Ministry of Education, College of Animal Science, Jilin University, Changchun, China.
  • Deng J; Key Laboratory of Zoonosis Research, Ministry of Education, College of Animal Science, Jilin University, Changchun, China.
  • Xu Y; Key Laboratory of Zoonosis Research, Ministry of Education, College of Animal Science, Jilin University, Changchun, China.
  • Lai L; Key Laboratory of Zoonosis Research, Ministry of Education, College of Animal Science, Jilin University, Changchun, China.
  • Li Z; CAS Key Laboratory of Regenerative Biology, Guangdong Provincial Key Laboratory of Stem Cell and Regenerative Medicine, South China Institute for Stem Cell Biology and Regenerative Medicine, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou, China.
RNA Biol ; 17(5): 623-629, 2020 05.
Article em En | MEDLINE | ID: mdl-32036747
ABSTRACT
The previous report shows the minimal promoter (P1) contributes to the Xist RNA activation in cells, while the role of the Xist P1 has not yet been investigated in animal individuals. Here, female Xist P1 knockout rabbits (Xist P1-/-) were generated for the studies. The results showed that there is no significant difference in transmission ratio, Xist and X-linked genes expression, and Xist RNA localization between the female wild type (WT) and Xist P1-/- rabbits, suggesting that P1 is non-essential for Xist expression and XCI in rabbits. Our study has explored the function of Xist P1 in animal level for the first time, and the results provide new ideas for future studies of XCI mechanisms.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Regiões Promotoras Genéticas / Inativação do Cromossomo X / Genes Ligados ao Cromossomo X / RNA Longo não Codificante Limite: Animals Idioma: En Ano de publicação: 2020 Tipo de documento: Article
Texto completo
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XML
PubMed Links
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Regiões Promotoras Genéticas / Inativação do Cromossomo X / Genes Ligados ao Cromossomo X / RNA Longo não Codificante Limite: Animals Idioma: En Ano de publicação: 2020 Tipo de documento: Article