Fibroblasts in the Tumor Microenvironment.
Adv Exp Med Biol
; 1234: 15-29, 2020.
Article
em En
| MEDLINE
| ID: mdl-32040852
ABSTRACT
The implications of a tumor microenvironment in cancer initiation and progression have drawn interest in recent years. Within the tumor stroma, fibroblasts represent a predominant cell type and are responsible for the majority of extracellular components within the tumor microenvironment, such as matrix and soluble factors. A switch from quiescent fibroblasts to cancer-associated fibroblasts triggers a large variety of pro-tumorigenic signals that support tumor progression and shape the surrounding pathological stroma, with the remodeling of tissue architecture and repression of the local immune response. The heterogeneous nature of cancer-associated fibroblasts and their multiple functions are subject of active research as they could represent promising targets for cutting-edge therapeutic approaches to cancer and the tumor microenvironment.
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Texto completo:
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Base de dados:
MEDLINE
Assunto principal:
Microambiente Tumoral
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Fibroblastos Associados a Câncer
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Neoplasias
Limite:
Humans
Idioma:
En
Ano de publicação:
2020
Tipo de documento:
Article