RASS-Enabled S/P-C and S-N Bond Formation for DEL Synthesis.

Flood, Dillon T; Zhang, Xuejing; Fu, Xiang; Zhao, Zhenxiang; Asai, Shota; Sanchez, Brittany B; Sturgell, Emily J; Vantourout, Julien C; Richardson, Paul; Flanagan, Mark E; Piotrowski, David W; Kölmel, Dominik K; Wan, Jinqiao; Tsai, Mei-Hsuan; Chen, Jason S; Baran, Phil S; Dawson, Philip E

Flood, Dillon T; Zhang, Xuejing; Fu, Xiang; Zhao, Zhenxiang; Asai, Shota; Sanchez, Brittany B; Sturgell, Emily J; Vantourout, Julien C; Richardson, Paul; Flanagan, Mark E; Piotrowski, David W; Kölmel, Dominik K; Wan, Jinqiao; Tsai, Mei-Hsuan; Chen, Jason S; Baran, Phil S; Dawson, Philip E.

Afiliação

Flood DT; Department of Chemistry, Scripps Research, 10550 N. Torrey Pines Road, La Jolla, CA, 92037, USA.
Zhang X; Department of Chemistry, Scripps Research, 10550 N. Torrey Pines Road, La Jolla, CA, 92037, USA.
Fu X; School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou, 510006, China.
Zhao Z; Department of Chemistry, Scripps Research, 10550 N. Torrey Pines Road, La Jolla, CA, 92037, USA.
Asai S; School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou, 510006, China.
Sanchez BB; Department of Chemistry, Scripps Research, 10550 N. Torrey Pines Road, La Jolla, CA, 92037, USA.
Sturgell EJ; Department of Chemistry and Biological Sciences, Faculty of and Engineering, Iwate University, 4-3-5 Ueda, Morioka, 020-8551, Japan.
Vantourout JC; Automated Synthesis Facility, The Scripps Research Institute, 10550 N. Torrey Pines Road, La Jolla, CA, 92037, USA.
Richardson P; Automated Synthesis Facility, The Scripps Research Institute, 10550 N. Torrey Pines Road, La Jolla, CA, 92037, USA.
Flanagan ME; Department of Chemistry, Scripps Research, 10550 N. Torrey Pines Road, La Jolla, CA, 92037, USA.
Piotrowski DW; Pfizer Medicinal Chemistry, 10770 Science Center Drive, San Diego, CA, 92121, USA.
Kölmel DK; Pfizer Medicinal Chemistry, Eastern Point Road, Groton, CT, 06340, USA.
Wan J; Pfizer Medicinal Chemistry, Eastern Point Road, Groton, CT, 06340, USA.
Tsai MH; Pfizer Medicinal Chemistry, Eastern Point Road, Groton, CT, 06340, USA.
Chen JS; HitGen Inc., Building 6, No. 8 Huigu 1st East Road Tianfu International Bio-Town, Shuangliu District, Chengdu, 610200, Sichuan, China.
Baran PS; HitGen Inc., Building 6, No. 8 Huigu 1st East Road Tianfu International Bio-Town, Shuangliu District, Chengdu, 610200, Sichuan, China.
Dawson PE; Automated Synthesis Facility, The Scripps Research Institute, 10550 N. Torrey Pines Road, La Jolla, CA, 92037, USA.

Angew Chem Int Ed Engl ; 59(19): 7377-7383, 2020 05 04.

Article em En | MEDLINE | ID: mdl-32050046

Assuntos

DNA/síntese química; Adsorção; Técnicas de Química Sintética; Técnicas de Química Combinatória; Descoberta de Drogas; Indicadores e Reagentes; Bibliotecas de Moléculas Pequenas; Solubilidade; Sulfonas/química; Sulfóxidos/química

Palavras-chave

DNA encoded library; nickel cross-coupling; reversible adsorption to solid support; sulfonamide; sulfone

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