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Failure of multiplex meningitis/encephalitis (ME) NAT during cryptococcal meningitis in solid organ recipients.
Pilmis, Benoit; Bougnoux, Marie-Elizabeth; Guery, Romain; Senghor, Yaye; Le Monnier, Alban; Lanternier, Fanny; Bretagne, Stephane; Alanio, Alexandre; Lortholary, Olivier.
Afiliação
  • Pilmis B; Service de Maladies Infectieuses et Tropicales, Centre d'Infectiologie Necker-Pasteur, Hôpital Necker-Enfants Malades, Assistance Publique des Hôpitaux de Paris (AP-HP), Université de Paris, Paris, France.
  • Bougnoux ME; Equipe Mobile de Microbiologie Clinique, Groupe Hospitalier Paris Saint-Joseph, Paris, France.
  • Guery R; EA4043 Unité Bactéries Pathogènes et Santé, Université Paris-Sud Saclay, Chatenay-Malabry, France.
  • Senghor Y; Unité de Parasitologie Mycologie, Hôpital Necker-Enfants Malades, Université de Paris, Paris, France.
  • Le Monnier A; Service de Maladies Infectieuses et Tropicales, Centre d'Infectiologie Necker-Pasteur, Hôpital Necker-Enfants Malades, Assistance Publique des Hôpitaux de Paris (AP-HP), Université de Paris, Paris, France.
  • Lanternier F; Service de Microbiologie Clinique, Groupe Hospitalier Paris Saint-Joseph, Paris, France.
  • Bretagne S; Service de Microbiologie Clinique, Groupe Hospitalier Paris Saint-Joseph, Paris, France.
  • Alanio A; Service de Maladies Infectieuses et Tropicales, Centre d'Infectiologie Necker-Pasteur, Hôpital Necker-Enfants Malades, Assistance Publique des Hôpitaux de Paris (AP-HP), Université de Paris, Paris, France.
  • Lortholary O; Institut Pasteur, Unité de Mycologie moléculaire, Centre national de référence des mycoses invasives et antifongiques, CNRS, UMR2000, Paris, France.
Transpl Infect Dis ; 22(4): e13263, 2020 Aug.
Article em En | MEDLINE | ID: mdl-32056348
ABSTRACT
Cryptococcal meningitis is a severe cause of central nervous system infections among immunocompromised solid organ transplant (SOT) patients. While new diagnostic methods as multiplex meningitis/encephalitis (ME) NAT (nucleic acid test) are increasingly used as a first-line tool in hospital practice, data in HIV-negative patients including SOT remain scarce. We report here false-negative results of multiplex NAT among SOT patients with proven cryptococcal meningitis.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Meningite Criptocócica / Hospedeiro Imunocomprometido / Erros de Diagnóstico / Reação em Cadeia da Polimerase Multiplex / Transplantados Tipo de estudo: Clinical_trials / Diagnostic_studies Limite: Humans / Male / Middle aged Idioma: En Ano de publicação: 2020 Tipo de documento: Article
Texto completo
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XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Meningite Criptocócica / Hospedeiro Imunocomprometido / Erros de Diagnóstico / Reação em Cadeia da Polimerase Multiplex / Transplantados Tipo de estudo: Clinical_trials / Diagnostic_studies Limite: Humans / Male / Middle aged Idioma: En Ano de publicação: 2020 Tipo de documento: Article