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Dehydrocostus lactone inhibits NLRP3 inflammasome activation by blocking ASC oligomerization and prevents LPS-mediated inflammation in vivo.
Chen, Yuanyuan; Li, Ruisheng; Wang, Zhilei; Hou, Xiaorong; Wang, Chunyu; Ai, Yongqiang; Shi, Wei; Zhan, Xiaoyan; Wang, Jia-Bo; Xiao, Xiaohe; Bai, Zhaofang; Sun, Hongsheng; Xu, Guang.
Afiliação
  • Chen Y; School of Pharmacy, Shandong University of Traditional Chinese Medicine, Jinan, China; Integrative Medical Center, The Fifth Medical Centre, Chinese PLA General Hospital, Beijing, China.
  • Li R; Research Center for Clinical and Translational Medicine, The Fifth Medical Centre, Chinese PLA General Hospital, Beijing, China.
  • Wang Z; Integrative Medical Center, The Fifth Medical Centre, Chinese PLA General Hospital, Beijing, China.
  • Hou X; Integrative Medical Center, The Fifth Medical Centre, Chinese PLA General Hospital, Beijing, China.
  • Wang C; Integrative Medical Center, The Fifth Medical Centre, Chinese PLA General Hospital, Beijing, China.
  • Ai Y; Integrative Medical Center, The Fifth Medical Centre, Chinese PLA General Hospital, Beijing, China.
  • Shi W; Integrative Medical Center, The Fifth Medical Centre, Chinese PLA General Hospital, Beijing, China.
  • Zhan X; Integrative Medical Center, The Fifth Medical Centre, Chinese PLA General Hospital, Beijing, China.
  • Wang JB; Integrative Medical Center, The Fifth Medical Centre, Chinese PLA General Hospital, Beijing, China.
  • Xiao X; Integrative Medical Center, The Fifth Medical Centre, Chinese PLA General Hospital, Beijing, China; China Military Institute of Chinese Materia, The Fifth Medical Centre, Chinese PLA General Hospital, Beijing, China.
  • Bai Z; Integrative Medical Center, The Fifth Medical Centre, Chinese PLA General Hospital, Beijing, China; China Military Institute of Chinese Materia, The Fifth Medical Centre, Chinese PLA General Hospital, Beijing, China.
  • Sun H; School of Pharmacy, Shandong University of Traditional Chinese Medicine, Jinan, China; Department of Pharmacy, Affiliated Hospital of Shandong University of Traditional Chinese Medicine, Jinan, China. Electronic address: shs7777@163.com.
  • Xu G; Integrative Medical Center, The Fifth Medical Centre, Chinese PLA General Hospital, Beijing, China; China Military Institute of Chinese Materia, The Fifth Medical Centre, Chinese PLA General Hospital, Beijing, China. Electronic address: 15811587486@139.com.
Cell Immunol ; 349: 104046, 2020 03.
Article em En | MEDLINE | ID: mdl-32057354
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Sesquiterpenos / Medicamentos de Ervas Chinesas / Leucócitos Mononucleares / Quimiotaxia de Leucócito / Inflamassomos / Proteína 3 que Contém Domínio de Pirina da Família NLR / Inflamação / Lactonas / Macrófagos Tipo de estudo: Prognostic_studies Limite: Adult / Animals / Female / Humans Idioma: En Ano de publicação: 2020 Tipo de documento: Article
Texto completo
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Sesquiterpenos / Medicamentos de Ervas Chinesas / Leucócitos Mononucleares / Quimiotaxia de Leucócito / Inflamassomos / Proteína 3 que Contém Domínio de Pirina da Família NLR / Inflamação / Lactonas / Macrófagos Tipo de estudo: Prognostic_studies Limite: Adult / Animals / Female / Humans Idioma: En Ano de publicação: 2020 Tipo de documento: Article