Recent advances in TRPV4 agonists and antagonists.
Bioorg Med Chem Lett
; 30(8): 127022, 2020 04 15.
Article
em En
| MEDLINE
| ID: mdl-32063431
ABSTRACT
TRPV4 is a ubiquitously expressed, non-selective cation channel activated by a range of stimuli including hypotonicity, temperature, pH, stretch and endogenous ligands. Agents that modulate TRPV4 are sought as potential therapeutics for the treatment of many diseases including osteoarthritis, respiratory illnesses, gastrointestinal disorders, pain and congestive heart failure. In recent years, significant advances in TRPV4 drug discovery have been realized as at least seven novel TRPV4 agonist or antagonist templates were reported and the first selective TRPV4 antagonist was evaluated in early clinical trials.
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Texto completo:
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Base de dados:
MEDLINE
Assunto principal:
Produtos Biológicos
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Forbóis
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Canais de Cátion TRPV
Limite:
Humans
Idioma:
En
Ano de publicação:
2020
Tipo de documento:
Article