Effects of clofibrate and KH176 on life span and motor function in mitochondrial complex I-deficient mice.

Frambach, Sanne J C M; van de Wal, Melissa A E; van den Broek, Petra H H; Smeitink, Jan A M; Russel, Frans G M; de Haas, Ria; Schirris, Tom J J

Frambach, Sanne J C M; van de Wal, Melissa A E; van den Broek, Petra H H; Smeitink, Jan A M; Russel, Frans G M; de Haas, Ria; Schirris, Tom J J.

Afiliação

Frambach SJCM; Department of Pharmacology and Toxicology, Radboud Institute for Molecular Life Sciences, Radboud University Medical Center, Nijmegen 6500 HB, the Netherlands; Radboud Center for Mitochondrial Medicine, Radboud University Medical Center, Nijmegen 6500 HB, the Netherlands.
van de Wal MAE; Department of Pharmacology and Toxicology, Radboud Institute for Molecular Life Sciences, Radboud University Medical Center, Nijmegen 6500 HB, the Netherlands; Radboud Center for Mitochondrial Medicine, Radboud University Medical Center, Nijmegen 6500 HB, the Netherlands.
van den Broek PHH; Department of Pharmacology and Toxicology, Radboud Institute for Molecular Life Sciences, Radboud University Medical Center, Nijmegen 6500 HB, the Netherlands.
Smeitink JAM; Radboud Center for Mitochondrial Medicine, Radboud University Medical Center, Nijmegen 6500 HB, the Netherlands; Department of Pediatrics, Radboud University Medical Center, Nijmegen 6500 HB, the Netherlands.
Russel FGM; Department of Pharmacology and Toxicology, Radboud Institute for Molecular Life Sciences, Radboud University Medical Center, Nijmegen 6500 HB, the Netherlands; Radboud Center for Mitochondrial Medicine, Radboud University Medical Center, Nijmegen 6500 HB, the Netherlands.
de Haas R; Radboud Center for Mitochondrial Medicine, Radboud University Medical Center, Nijmegen 6500 HB, the Netherlands; Department of Pediatrics, Radboud University Medical Center, Nijmegen 6500 HB, the Netherlands.
Schirris TJJ; Department of Pharmacology and Toxicology, Radboud Institute for Molecular Life Sciences, Radboud University Medical Center, Nijmegen 6500 HB, the Netherlands; Radboud Center for Mitochondrial Medicine, Radboud University Medical Center, Nijmegen 6500 HB, the Netherlands. Electronic address: Tom.Sch

Biochim Biophys Acta Mol Basis Dis ; 1866(6): 165727, 2020 06 01.

Article em En | MEDLINE | ID: mdl-32070771

Assuntos

Cromanos/farmacologia; Clofibrato/farmacologia; Complexo I de Transporte de Elétrons/deficiência; Longevidade/efeitos dos fármacos; Doenças Mitocondriais/tratamento farmacológico; Trifosfato de Adenosina/metabolismo; Animais; Bezafibrato/farmacologia; Complexo I de Transporte de Elétrons/genética; Complexo I de Transporte de Elétrons/metabolismo; Ácidos Graxos/metabolismo; Humanos; Doença de Leigh/tratamento farmacológico; Doença de Leigh/metabolismo; Doença de Leigh/patologia; Camundongos; Camundongos Knockout; Mitocôndrias/efeitos dos fármacos; Doenças Mitocondriais/metabolismo; Doenças Mitocondriais/patologia; Atividade Motora/efeitos dos fármacos; Oxirredução/efeitos dos fármacos; Receptores Ativados por Proliferador de Peroxissomo/agonistas; Receptores Ativados por Proliferador de Peroxissomo/genética

Palavras-chave

Clofibrate; Hepatotoxicity; KH176; Mitochondrial complex I deficiency; Peroxisome proliferator activated receptor (PPAR); Redox modulator

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Cromanos / Clofibrato / Doenças Mitocondriais / Complexo I de Transporte de Elétrons / Longevidade Limite: Animals / Humans Idioma: En Ano de publicação: 2020 Tipo de documento: Article

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