Adipose-derived exosomes protect the pulmonary endothelial barrier in ventilator-induced lung injury by inhibiting the TRPV4/Ca<sup>2+</sup> signaling pathway.

Yu, Qian; Wang, Daoxin; Wen, Xiaoting; Tang, Xumao; Qi, Di; He, Jing; Zhao, Yan; Deng, Wang; Zhu, Tao

Adipose-derived exosomes protect the pulmonary endothelial barrier in ventilator-induced lung injury by inhibiting the TRPV4/Ca²⁺ signaling pathway.

Yu, Qian; Wang, Daoxin; Wen, Xiaoting; Tang, Xumao; Qi, Di; He, Jing; Zhao, Yan; Deng, Wang; Zhu, Tao.

Afiliação

Yu Q; Department of Respiratory Medicine, Second Affiliated Hospital of Chongqing Medical University, Chongqing, China.
Wang D; Department of Respiratory Medicine, Second Affiliated Hospital of Chongqing Medical University, Chongqing, China.
Wen X; Department of Respiratory Medicine, Second Affiliated Hospital of Chongqing Medical University, Chongqing, China.
Tang X; Department of Respiratory Medicine, Second Affiliated Hospital of Chongqing Medical University, Chongqing, China.
Qi D; Department of Respiratory Medicine, Second Affiliated Hospital of Chongqing Medical University, Chongqing, China.
He J; Department of Respiratory Medicine, Second Affiliated Hospital of Chongqing Medical University, Chongqing, China.
Zhao Y; Department of Respiratory Medicine, Second Affiliated Hospital of Chongqing Medical University, Chongqing, China.
Deng W; Department of Respiratory Medicine, Second Affiliated Hospital of Chongqing Medical University, Chongqing, China.
Zhu T; Department of Respiratory Medicine, Second Affiliated Hospital of Chongqing Medical University, Chongqing, China.

Am J Physiol Lung Cell Mol Physiol ; 318(4): L723-L741, 2020 04 01.

Article em En | MEDLINE | ID: mdl-32073873

Assuntos

Sinalização do Cálcio/fisiologia; Cálcio/metabolismo; Células Endoteliais/metabolismo; Exossomos/metabolismo; Síndrome do Desconforto Respiratório/metabolismo; Canais de Cátion TRPV/metabolismo; Lesão Pulmonar Induzida por Ventilação Mecânica/metabolismo; Junções Aderentes/metabolismo; Animais; Pulmão/metabolismo; Masculino; Camundongos; Camundongos Endogâmicos C57BL; Obesidade/metabolismo; Respiração Artificial/efeitos adversos; Transdução de Sinais/fisiologia; Volume de Ventilação Pulmonar/fisiologia

Palavras-chave

TRPV4; adipose-derived exosomes; inflammation; pulmonary endothelial barrier; ventilator-induced lung injury (VILI)

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Síndrome do Desconforto Respiratório / Cálcio / Sinalização do Cálcio / Células Endoteliais / Canais de Cátion TRPV / Exossomos / Lesão Pulmonar Induzida por Ventilação Mecânica Limite: Animals Idioma: En Ano de publicação: 2020 Tipo de documento: Article

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