Angiotensin II for the emergency physician.
Emerg Med J
; 37(11): 717-721, 2020 Nov.
Article
em En
| MEDLINE
| ID: mdl-32075849
ABSTRACT
Refractory hypotension is one of the most common and difficult clinical problems faced by acute care clinicians, and it poses a particularly large problem to the emergency physician when a patient in undifferentiated shock arrives in the department. Angiotensin II (Ang-2) has been previously used as a vasopressor to combat shock; the feasibility of its clinical use has been reinvigorated after approval of a human synthetic formulation of the medication by the US Food and Drug Administration in 2017 and the European Medicines Agency in 2019. A thorough literature search was completed, and in this review, we discuss the discovery and development of Ang-2, its complex mechanisms of vasoconstriction, its potential adverse effects and its potential role in clinical practice for emergency physicians.
Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Choque
/
Vasoconstritores
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Angiotensina II
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Cuidados Críticos
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Serviço Hospitalar de Emergência
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Hipotensão
Limite:
Humans
Idioma:
En
Ano de publicação:
2020
Tipo de documento:
Article