Prevention of calcium-induced membrane structural alterations in erythrocyte membranes by flunarizine.
Biochim Biophys Acta
; 946(2): 439-44, 1988 Dec 22.
Article
em En
| MEDLINE
| ID: mdl-3207759
ABSTRACT
The calcium antagonist flunarizine is shown to be able to prevent particle aggregation, membrane aggregation and blebbing resulting from elevated calcium concentrations. The anti-ischemic effects of flunarizine may therefore result in part from its ability to directly interfere with calcium-membrane interactions and thus prevent the lethal membrane reorganizations which occur after a period of ischemia during intracellular calcium overload.
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Base de dados:
MEDLINE
Assunto principal:
Flunarizina
/
Cálcio
/
Membrana Eritrocítica
Limite:
Humans
Idioma:
En
Ano de publicação:
1988
Tipo de documento:
Article