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Inhibition of IL-1beta improves Glycaemia in a Mouse Model for Gestational Diabetes.
Schulze, Friederike; Wehner, Josua; Kratschmar, Denise V; Makshana, Valmir; Meier, Daniel T; Häuselmann, Stéphanie P; Dalmas, Elise; Thienel, Constanze; Dror, Erez; Wiedemann, Sophia J; Traub, Shuyang; Nordmann, Thierry M; Rachid, Leila; De Baat, Axel; Rohm, Theresa V; Zhao, Cheng; Odermatt, Alex; Böni-Schnetzler, Marianne; Donath, Marc Y.
Afiliação
  • Schulze F; Clinic of Endocrinology, Diabetes and Metabolism, University Hospital Basel, Basel, Switzerland and Department of Biomedicine, University of Basel, Basel, Switzerland. schulze.fritzi@gmail.com.
  • Wehner J; Clinic of Endocrinology, Diabetes and Metabolism, University Hospital Basel, Basel, Switzerland and Department of Biomedicine, University of Basel, Basel, Switzerland.
  • Kratschmar DV; Division of Molecular and Systems Toxicology, Department of Pharmaceutical Sciences, University of Basel, Basel, Switzerland.
  • Makshana V; Clinic of Endocrinology, Diabetes and Metabolism, University Hospital Basel, Basel, Switzerland and Department of Biomedicine, University of Basel, Basel, Switzerland.
  • Meier DT; Clinic of Endocrinology, Diabetes and Metabolism, University Hospital Basel, Basel, Switzerland and Department of Biomedicine, University of Basel, Basel, Switzerland.
  • Häuselmann SP; Clinic of Endocrinology, Diabetes and Metabolism, University Hospital Basel, Basel, Switzerland and Department of Biomedicine, University of Basel, Basel, Switzerland.
  • Dalmas E; Clinic of Endocrinology, Diabetes and Metabolism, University Hospital Basel, Basel, Switzerland and Department of Biomedicine, University of Basel, Basel, Switzerland.
  • Thienel C; Clinic of Endocrinology, Diabetes and Metabolism, University Hospital Basel, Basel, Switzerland and Department of Biomedicine, University of Basel, Basel, Switzerland.
  • Dror E; Clinic of Endocrinology, Diabetes and Metabolism, University Hospital Basel, Basel, Switzerland and Department of Biomedicine, University of Basel, Basel, Switzerland.
  • Wiedemann SJ; Clinic of Endocrinology, Diabetes and Metabolism, University Hospital Basel, Basel, Switzerland and Department of Biomedicine, University of Basel, Basel, Switzerland.
  • Traub S; Clinic of Endocrinology, Diabetes and Metabolism, University Hospital Basel, Basel, Switzerland and Department of Biomedicine, University of Basel, Basel, Switzerland.
  • Nordmann TM; Clinic of Endocrinology, Diabetes and Metabolism, University Hospital Basel, Basel, Switzerland and Department of Biomedicine, University of Basel, Basel, Switzerland.
  • Rachid L; Clinic of Endocrinology, Diabetes and Metabolism, University Hospital Basel, Basel, Switzerland and Department of Biomedicine, University of Basel, Basel, Switzerland.
  • De Baat A; Clinic of Endocrinology, Diabetes and Metabolism, University Hospital Basel, Basel, Switzerland and Department of Biomedicine, University of Basel, Basel, Switzerland.
  • Rohm TV; Clinic of Endocrinology, Diabetes and Metabolism, University Hospital Basel, Basel, Switzerland and Department of Biomedicine, University of Basel, Basel, Switzerland.
  • Zhao C; Clinic of Endocrinology, Diabetes and Metabolism, University Hospital Basel, Basel, Switzerland and Department of Biomedicine, University of Basel, Basel, Switzerland.
  • Odermatt A; Division of Molecular and Systems Toxicology, Department of Pharmaceutical Sciences, University of Basel, Basel, Switzerland.
  • Böni-Schnetzler M; Clinic of Endocrinology, Diabetes and Metabolism, University Hospital Basel, Basel, Switzerland and Department of Biomedicine, University of Basel, Basel, Switzerland.
  • Donath MY; Clinic of Endocrinology, Diabetes and Metabolism, University Hospital Basel, Basel, Switzerland and Department of Biomedicine, University of Basel, Basel, Switzerland.
Sci Rep ; 10(1): 3035, 2020 02 20.
Article em En | MEDLINE | ID: mdl-32080229
ABSTRACT
Gestational diabetes mellitus (GDM) is one of the most common diseases associated with pregnancy, however, the underlying mechanisms remain unclear. Based on the well documented role of inflammation in type 2 diabetes, the aim was to investigate the role of inflammation in GDM. We established a mouse model for GDM on the basis of its two major risk factors, obesity and aging. In these GDM mice, we observed increased Interleukin-1ß (IL-1ß) expression in the uterus and the placenta along with elevated circulating IL-1ß concentrations compared to normoglycemic pregnant mice. Treatment with an anti-IL-1ß antibody improved glucose-tolerance of GDM mice without apparent deleterious effects for the fetus. Finally, IL-1ß antagonism showed a tendency for reduced plasma corticosterone concentrations, possibly explaining the metabolic improvement. We conclude that IL-1ß is a causal driver of impaired glucose tolerance in GDM.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Diabetes Gestacional / Interleucina-1beta / Hiperglicemia Tipo de estudo: Prognostic_studies / Risk_factors_studies Limite: Animals / Pregnancy Idioma: En Ano de publicação: 2020 Tipo de documento: Article
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Diabetes Gestacional / Interleucina-1beta / Hiperglicemia Tipo de estudo: Prognostic_studies / Risk_factors_studies Limite: Animals / Pregnancy Idioma: En Ano de publicação: 2020 Tipo de documento: Article