Expression profiles of circular RNA in granulosa cells from women with biochemical premature ovarian insufficiency.
Epigenomics
; 12(4): 319-332, 2020 02.
Article
em En
| MEDLINE
| ID: mdl-32081025
ABSTRACT
Aim:
To identify the expression profiles and potential functions of circular RNAs (circRNAs) in granulosa cells (GCs) from women with biochemical premature ovarian insufficiency (bPOI). Patients &methods:
CircRNAs microarray analysis was performed to GCs from 8 patients with bPOI and 8 control women, followed by qRT-PCR in 15 paired samples. CircRNA-miRNA networks and the prediction of their enriched signaling pathways were conducted by bioinformatics analysis.Results:
A total of 133 upregulated and 424 downregulated circRNAs was identified in women with bPOI. We constructed circRNA-miRNA networks and found that the most predominantly enriched signaling pathways were the FoxO signaling pathway and cellular senescence.Conclusion:
CircRNAs are differentially expressed in bPOI, which might contribute to the pathogenesis of bPOI.Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Insuficiência Ovariana Primária
/
RNA Circular
/
Células da Granulosa
Tipo de estudo:
Diagnostic_studies
/
Prognostic_studies
Limite:
Adult
/
Female
/
Humans
Idioma:
En
Ano de publicação:
2020
Tipo de documento:
Article