Evaluation of self-emulsifying drug delivery systems for oral insulin delivery using an in vitro model simulating the intestinal proteolysis.

Liu, Jingying; Hirschberg, Cosima; Fanø, Mathias; Mu, Huiling; Müllertz, Anette

Liu, Jingying; Hirschberg, Cosima; Fanø, Mathias; Mu, Huiling; Müllertz, Anette.

Afiliação

Liu J; Department of Pharmacy, Faculty of Health and Medical Sciences, University of Copenhagen, 2100, Copenhagen, Denmark.
Hirschberg C; Department of Pharmacy, Faculty of Health and Medical Sciences, University of Copenhagen, 2100, Copenhagen, Denmark.
Fanø M; Bioneer: FARMA, Faculty of Health and Medical Sciences, University of Copenhagen, Universitetsparken 2, 2100 Copenhagen, Denmark.
Mu H; Department of Pharmacy, Faculty of Health and Medical Sciences, University of Copenhagen, 2100, Copenhagen, Denmark.
Müllertz A; Department of Pharmacy, Faculty of Health and Medical Sciences, University of Copenhagen, 2100, Copenhagen, Denmark; Bioneer: FARMA, Faculty of Health and Medical Sciences, University of Copenhagen, Universitetsparken 2, 2100 Copenhagen, Denmark. Electronic address: anette.mullertz@sund.ku.dk.

Eur J Pharm Sci ; 147: 105272, 2020 Apr 30.

Article em En | MEDLINE | ID: mdl-32084584

Assuntos

Sistemas de Liberação de Medicamentos/métodos; Emulsões/química; Técnicas In Vitro; Insulina/administração & dosagem; Administração Oral; Quimotripsina/metabolismo; Hidrólise; Intestinos; Proteólise

Palavras-chave

Development of SEDDS; In vitro proteolysis; Insulin; Oral delivery; Principal component analysis; Self-emulsifying drug delivery systems

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Técnicas In Vitro / Sistemas de Liberação de Medicamentos / Emulsões / Insulina Idioma: En Ano de publicação: 2020 Tipo de documento: Article

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