Endocrine-Disrupting Chemicals in Human Fetal Growth.
Int J Mol Sci
; 21(4)2020 Feb 20.
Article
em En
| MEDLINE
| ID: mdl-32093249
ABSTRACT
Fetal growth is regulated by a complex interaction of maternal, placental, and fetal factors. The effects and outcomes that chemicals, widely distributed in the environment, may have on the health status of both the mother and the fetus are not yet well defined. Mainly mixtures of chemical substances are found in the mothers and placenta. Exposure to endocrine-disrupting chemicals (EDCs) can be associated with fetal growth retardation, thyroid dysfunction, and neurological disorders. EDCs mostly interfere with insulin, glucocorticoid, estrogenic, and thyroid pathways, with subsequent effects on normal endocrine and metabolic functions, which cause changes in the epigenome and state of inflammation with life-long effects and consequences. International scientific societies recommend the implementation of research and of all possible preventive measures. This review briefly summarizes all these aspects.
Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Doenças da Glândula Tireoide
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Exposição Materna
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Desenvolvimento Fetal
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Disruptores Endócrinos
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Retardo do Crescimento Fetal
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Doenças do Sistema Nervoso
Limite:
Female
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Humans
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Pregnancy
Idioma:
En
Ano de publicação:
2020
Tipo de documento:
Article