Atranorin, an antimicrobial metabolite from lichen <i>Parmotrema rampoddense</i> exhibited in vitro anti-breast cancer activity through interaction with Akt activity.

Harikrishnan, Adhikesavan; Veena, V; Lakshmi, B; Shanmugavalli, R; Theres, Sonia; Prashantha, C N; Shah, Tanya; Oshin, K; Togam, Ringu; Nandi, Sisir

Atranorin, an antimicrobial metabolite from lichen Parmotrema rampoddense exhibited in vitro anti-breast cancer activity through interaction with Akt activity.

Harikrishnan, Adhikesavan; Veena, V; Lakshmi, B; Shanmugavalli, R; Theres, Sonia; Prashantha, C N; Shah, Tanya; Oshin, K; Togam, Ringu; Nandi, Sisir.

Afiliação

Harikrishnan A; Department of Chemistry, School of Arts and Sciences, Vinayaka Mission Research Foundation-Aarupadai Veedu (VMRF-AV) Campus, Chennai, Tamil Nadu, India.
Veena V; Department of Biotechnology, School of Applied Sciences, REVA University, Bangalore, Karnataka, India.
Lakshmi B; Department of Chemistry, School of Applied Sciences, REVA University, Bangalore, Karnataka, India.
Shanmugavalli R; Department of Chemistry, School of Arts and Sciences, Vinayaka Mission Research Foundation-Aarupadai Veedu (VMRF-AV) Campus, Chennai, Tamil Nadu, India.
Theres S; Department of Chemistry, Kanchi Mamunivar Centre for Postgraduate Studies (KMCPGS), Puducherry, India.
Prashantha CN; Department of Biotechnology, School of Applied Sciences, REVA University, Bangalore, Karnataka, India.
Shah T; Department of Biotechnology, School of Applied Sciences, REVA University, Bangalore, Karnataka, India.
Oshin K; Department of Biotechnology, School of Applied Sciences, REVA University, Bangalore, Karnataka, India.
Togam R; Department of Biotechnology, School of Applied Sciences, REVA University, Bangalore, Karnataka, India.
Nandi S; Department of Pharmaceutical Chemistry, Global Institute of Pharmaceutical Education and Research (GIPER), Affiliated to Uttarakhand Technical University, Kashipur, Uttarakhand, India.

J Biomol Struct Dyn ; 39(4): 1248-1258, 2021 Mar.

Article em En | MEDLINE | ID: mdl-32096436

Assuntos

Anti-Infecciosos; Neoplasias da Mama; Líquens; Anti-Infecciosos/farmacologia; Apoptose; Ascomicetos; Neoplasias da Mama/tratamento farmacológico; Linhagem Celular Tumoral; Feminino; Humanos; Hidroxibenzoatos; Simulação de Acoplamento Molecular; Proteínas Proto-Oncogênicas c-akt; Proteínas Proto-Oncogênicas c-bcl-2

Palavras-chave

Breast cancer; atranorin; biological validation; cytotoxicity; interaction

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Neoplasias da Mama / Líquens / Anti-Infecciosos Limite: Female / Humans Idioma: En Ano de publicação: 2021 Tipo de documento: Article

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