Lineage Assignment in Acute Leukemia: A Challenging Case in a Pediatric Patient.
J Pediatr Hematol Oncol
; 43(1): e109-e114, 2021 01.
Article
em En
| MEDLINE
| ID: mdl-32097282
ABSTRACT
We report a case of a 2-year-old girl who was diagnosed with natural killer cell acute lymphoblastic leukemia and treated with an acute lymphoblastic leukemia chemotherapy regimen. Two months posttherapy, the disease relapsed with a myeloid immunophenotype. Complete response was then achieved with acute myeloid leukemia therapy followed by unrelated donor umbilical cord allogenic stem cell transplant. Retrospectively, reanalysis of the diagnostic specimen showed minimal myeloperoxidase expression that was called negative by conventional single parameter linear gating but better appreciated on histogram overlays. This case illustrates that even low levels of myeloperoxidase expression should be considered significant in lineage assignment in acute leukemia.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Células Matadoras Naturais
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Leucemia Mieloide Aguda
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Protocolos de Quimioterapia Combinada Antineoplásica
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Linhagem da Célula
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Transplante de Células-Tronco de Sangue do Cordão Umbilical
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Leucemia-Linfoma Linfoblástico de Células Precursoras
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Recidiva Local de Neoplasia
Tipo de estudo:
Diagnostic_studies
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Observational_studies
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Prognostic_studies
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Risk_factors_studies
Limite:
Child, preschool
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Female
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Humans
Idioma:
En
Ano de publicação:
2021
Tipo de documento:
Article