Discovery of antitumor lectins from rainforest tree root transcriptomes.

Lawanprasert, Atip; Guinan, Caitlin A; Langford, Erica A; Hawkins, Carly E; Sloand, Janna N; Fescemyer, Howard W; Aronson, Matthew R; Halle, Jacob A; Marden, James H; Medina, Scott H

Lawanprasert, Atip; Guinan, Caitlin A; Langford, Erica A; Hawkins, Carly E; Sloand, Janna N; Fescemyer, Howard W; Aronson, Matthew R; Halle, Jacob A; Marden, James H; Medina, Scott H.

Afiliação

Lawanprasert A; Department of Biomedical Engineering, Penn State University, University Park, PA, United States of America.
Guinan CA; Department of Biology, Penn State University, University Park, PA, United States of America.
Langford EA; Department of Biology, Penn State University, University Park, PA, United States of America.
Hawkins CE; Department of Biology, Penn State University, University Park, PA, United States of America.
Sloand JN; Department of Biomedical Engineering, Penn State University, University Park, PA, United States of America.
Fescemyer HW; Department of Biology, Penn State University, University Park, PA, United States of America.
Aronson MR; Department of Biomedical Engineering, Penn State University, University Park, PA, United States of America.
Halle JA; Department of Biomedical Engineering, Penn State University, University Park, PA, United States of America.
Marden JH; Department of Biology, Penn State University, University Park, PA, United States of America.
Medina SH; Huck Institutes of the Life Sciences, Penn State University, University Park, PA, United States of America.

PLoS One ; 15(2): e0229467, 2020.

Article em En | MEDLINE | ID: mdl-32097449

Assuntos

Antineoplásicos/farmacologia; Lectinas de Ligação a Manose/farmacologia; Neoplasias/tratamento farmacológico; Extratos Vegetais/farmacologia; Raízes de Plantas/química; Transcriptoma; Árvores/química; Sequência de Aminoácidos; Antineoplásicos/química; Apoptose; Proliferação de Células; Descoberta de Drogas; Glicosilação; Humanos; Lectinas de Ligação a Manose/química; Modelos Moleculares; Neoplasias/genética; Neoplasias/patologia; Polissacarídeos/metabolismo; Conformação Proteica; Floresta Úmida; Células Tumorais Cultivadas

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Árvores / Extratos Vegetais / Raízes de Plantas / Lectinas de Ligação a Manose / Transcriptoma / Neoplasias / Antineoplásicos Limite: Humans Idioma: En Ano de publicação: 2020 Tipo de documento: Article

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