On Epigenetic Plasticity and Genome Topology.

Lazaris, Charalampos; Aifantis, Iannis; Tsirigos, Aristotelis

Lazaris, Charalampos; Aifantis, Iannis; Tsirigos, Aristotelis.

Afiliação

Lazaris C; Department of Pathology, New York University School of Medicine, New York, NY 10016, USA; Laura & Isaac Perlmutter Cancer Center, New York University School of Medicine, New York, NY 10016, USA. Electronic address: lazaris@wi.mit.edu.
Aifantis I; Department of Pathology, New York University School of Medicine, New York, NY 10016, USA; Laura & Isaac Perlmutter Cancer Center, New York University School of Medicine, New York, NY 10016, USA.
Tsirigos A; Department of Pathology, New York University School of Medicine, New York, NY 10016, USA; Laura & Isaac Perlmutter Cancer Center, New York University School of Medicine, New York, NY 10016, USA; Applied Bioinformatics Laboratories, Office of Science & Research, New York University School of Medicine, New York, NY 10016, USA.

Trends Cancer ; 6(3): 177-180, 2020 03.

Article em En | MEDLINE | ID: mdl-32101721

ABSTRACT

ABSTRACT

Mounting evidence links genetic lesions with genome topology alterations and aberrant gene activation. However, the role of epigenetic plasticity remains elusive. Emerging studies implicate DNA methylation, transcriptional elongation, long noncoding RNAs (lncRNAs), and CCCTC-binding factor (CTCF)-RNA interactions, but systematic approaches are needed to fully decipher the role of epigenetic plasticity in genome integrity and function.

Assuntos

Epigenômica; Regulação Neoplásica da Expressão Gênica; Genoma Humano; Neoplasias/genética; Transformação Celular Neoplásica/genética; Cromatina/genética; Cromatina/ultraestrutura; Regulação Neoplásica da Expressão Gênica/genética; Humanos; Modelos Genéticos; Oncogenes; Transcrição Gênica

Palavras-chave

TAD boundaries; cancer; epigenetic plasticity; genome organization; topologically associating domains (TADs); transcriptional dysregulation

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Regulação Neoplásica da Expressão Gênica / Genoma Humano / Epigenômica / Neoplasias Tipo de estudo: Prognostic_studies Limite: Humans Idioma: En Ano de publicação: 2020 Tipo de documento: Article

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