Synthesis and characterization of high affinity fluorogenic α-synuclein probes.
Chem Commun (Camb)
; 56(24): 3567-3570, 2020 Mar 24.
Article
em En
| MEDLINE
| ID: mdl-32104795
ABSTRACT
Fluorescent small molecules are powerful tools for imaging α-synuclein pathology in vitro and in vivo. In this work, we explore benzofuranone as a potential scaffold for the design of fluorescent α-synuclein probes. These compounds have high affinity for α-synuclein, show fluorescent turn-on upon binding to fibrils, and display different binding to Lewy bodies, Lewy neurites and glial cytoplasmic inclusion pathologies in post-mortem brain tissue. These studies not only reveal the potential of benzofuranone compounds as α-synuclein specific fluorescent probes, but also have implications for the ways in which α-synucleinopathies are conformationally different and display distinct small molecule binding sites.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Benzofuranos
/
Alfa-Sinucleína
/
Corantes Fluorescentes
Limite:
Humans
Idioma:
En
Ano de publicação:
2020
Tipo de documento:
Article