Reporter cell assay-based functional quantification of TNF-&#945;-antagonists in serum - a proof-of-principle study for adalimumab.

Schuster, Lukas; Sauter, Max; Uhl, Philipp; Meid, Andreas; Haefeli, Walter E; Weiss, Johanna; Theile, Dirk

Reporter cell assay-based functional quantification of TNF-α-antagonists in serum - a proof-of-principle study for adalimumab.

Schuster, Lukas; Sauter, Max; Uhl, Philipp; Meid, Andreas; Haefeli, Walter E; Weiss, Johanna; Theile, Dirk.

Afiliação

Schuster L; Department of Clinical Pharmacology and Pharmacoepidemiology, Heidelberg University Hospital, Im Neuenheimer Feld 410, 69120, Heidelberg, Germany.
Sauter M; Department of Clinical Pharmacology and Pharmacoepidemiology, Heidelberg University Hospital, Im Neuenheimer Feld 410, 69120, Heidelberg, Germany.
Uhl P; Department of Clinical Pharmacology and Pharmacoepidemiology, Heidelberg University Hospital, Im Neuenheimer Feld 410, 69120, Heidelberg, Germany.
Meid A; Department of Clinical Pharmacology and Pharmacoepidemiology, Heidelberg University Hospital, Im Neuenheimer Feld 410, 69120, Heidelberg, Germany.
Haefeli WE; Department of Clinical Pharmacology and Pharmacoepidemiology, Heidelberg University Hospital, Im Neuenheimer Feld 410, 69120, Heidelberg, Germany.
Weiss J; Department of Clinical Pharmacology and Pharmacoepidemiology, Heidelberg University Hospital, Im Neuenheimer Feld 410, 69120, Heidelberg, Germany.
Theile D; Department of Clinical Pharmacology and Pharmacoepidemiology, Heidelberg University Hospital, Im Neuenheimer Feld 410, 69120, Heidelberg, Germany. Electronic address: dirk.theile@med.uni-heidelberg.de.

Anal Biochem ; 596: 113646, 2020 05 01.

Article em En | MEDLINE | ID: mdl-32112722

Assuntos

Adalimumab/sangue; Adalimumab/farmacologia; Fator de Necrose Tumoral alfa/antagonistas & inibidores; Adalimumab/administração & dosagem; Administração Intravenosa; Animais; Células Cultivadas; Cães; Ensaio de Imunoadsorção Enzimática; Células HEK293; Humanos

Palavras-chave

Adalimumab; HEK-Blue™-hTLR3; NF-κB; Reporter cell assay; Tumor necrosis factor

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Fator de Necrose Tumoral alfa / Adalimumab Limite: Animals / Humans Idioma: En Ano de publicação: 2020 Tipo de documento: Article

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google