Hypersensitivity reactions to proton-pump inhibitors: Clinical presentation, diagnosis, and management.
Allergy Asthma Proc
; 41(2): e37-e44, 2020 03 01.
Article
em En
| MEDLINE
| ID: mdl-32122452
ABSTRACT
Background:
Proton-pump inhibitors (PPI) are one of the most commonly prescribed drugs, and they are generally well tolerated. However, several immediate and delayed hypersensitivity reactions due to PPIs have been reported.Objective:
To review the clinical characteristics and management of immune-mediated immediate and delayed hypersensitivity reactions to PPIs.Methods:
We performed a search of a medical literature data base from January 1980 to October 2019 by using keywords that included "proton-pump inhibitors" and "hypersensitivity."Results:
Anaphylaxis is the most-common clinical presentation in patients with immediate hypersensitivity reactions to PPIs, followed by urticaria and/or angioedema. Occupational contact dermatitis, maculopapular eruption, fixed drug eruption, symmetrical drug-related intertriginous and flexural exanthema, and severe cutaneous adverse reactions, such as Stevens-Johnson syndrome, toxic epidermal necrolysis, drug rash with eosinophilia and systemic symptoms, and acute generalized exanthematous pustulosis have also been reported with PPIs.Conclusion:
The current knowledge and severity of the reported reactions indicated the importance of consideration of a causal relationship between hypersensitivity reactions and PPIs, and awareness of the existence of cross-reactivity among PPIs.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Pele
/
Hipersensibilidade a Drogas
/
Inibidores da Bomba de Prótons
/
Anafilaxia
Tipo de estudo:
Diagnostic_studies
Limite:
Animals
/
Humans
Idioma:
En
Ano de publicação:
2020
Tipo de documento:
Article