Exploring the protective effects of schizandrol A in acute myocardial ischemia mice by comprehensive metabolomics profiling integrated with molecular mechanism studies.

Lai, Qiong; Yuan, Guang-Ying; Wang, Hao; Liu, Ze-Liang; Kou, Jun-Ping; Yu, Bo-Yang; Li, Fang

Lai, Qiong; Yuan, Guang-Ying; Wang, Hao; Liu, Ze-Liang; Kou, Jun-Ping; Yu, Bo-Yang; Li, Fang.

Afiliação

Lai Q; Jiangsu Key Laboratory of TCM Evaluation and Translational Research, Research Center for Traceability and Standardization of TCMs, School of Traditional Chinese Pharmacy, China Pharmaceutical University, Nanjing, 211199, China.
Yuan GY; Jiangsu Key Laboratory of TCM Evaluation and Translational Research, Research Center for Traceability and Standardization of TCMs, School of Traditional Chinese Pharmacy, China Pharmaceutical University, Nanjing, 211199, China.
Wang H; Jiangsu Province Hospital of Chinese Medicine, Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing University of Chinese Medicine, Nanjing, 210046, China.
Liu ZL; Jiangsu Key Laboratory of TCM Evaluation and Translational Research, Research Center for Traceability and Standardization of TCMs, School of Traditional Chinese Pharmacy, China Pharmaceutical University, Nanjing, 211199, China.
Kou JP; Jiangsu Key Laboratory of TCM Evaluation and Translational Research, Research Center for Traceability and Standardization of TCMs, School of Traditional Chinese Pharmacy, China Pharmaceutical University, Nanjing, 211199, China.
Yu BY; Jiangsu Key Laboratory of TCM Evaluation and Translational Research, Research Center for Traceability and Standardization of TCMs, School of Traditional Chinese Pharmacy, China Pharmaceutical University, Nanjing, 211199, China. boyangyu59@163.com.
Li F; Jiangsu Key Laboratory of TCM Evaluation and Translational Research, Research Center for Traceability and Standardization of TCMs, School of Traditional Chinese Pharmacy, China Pharmaceutical University, Nanjing, 211199, China. lifangcpu@163.com.

Acta Pharmacol Sin ; 41(8): 1058-1072, 2020 Aug.

Article em En | MEDLINE | ID: mdl-32123298

Assuntos

Cardiotônicos/uso terapêutico; Ciclo-Octanos/uso terapêutico; Lignanas/uso terapêutico; Isquemia Miocárdica/tratamento farmacológico; Compostos Policíclicos/uso terapêutico; Animais; Apoptose/efeitos dos fármacos; Linhagem Celular; Enzimas/metabolismo; Masculino; Metabolômica; Camundongos Endogâmicos ICR; Isquemia Miocárdica/patologia; Miocárdio/patologia; Miócitos Cardíacos/efeitos dos fármacos; Mapas de Interação de Proteínas; Ratos; Transdução de Sinais/efeitos dos fármacos

Palavras-chave

OGD-treated H9c2 cardiomycytes; acute myocardial ischemia mice; cardioprotective effect; metabolic pathways; metabonomics; schizandrol A; therapeutic targets

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Compostos Policíclicos / Cardiotônicos / Isquemia Miocárdica / Lignanas / Ciclo-Octanos Limite: Animals Idioma: En Ano de publicação: 2020 Tipo de documento: Article

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