Estimation of passive gastrointestinal absorption and membrane retention using PAMPA test, quantitative structure-permeability and quantitative structure-retention relationship analyses of ethylenediamine-N,N'-di-2-(3-cyclohexyl)propanoic acid and 1,3-propanediamine-N,N'-di-2-(3-cyclohexyl)propanoic acid derivatives.

Tubic, Biljana; Dobricic, Vladimir; Poljarevic, Jelena; Savic, Aleksandar; Sabo, Tibor; Markovic, Bojan

Tubic, Biljana; Dobricic, Vladimir; Poljarevic, Jelena; Savic, Aleksandar; Sabo, Tibor; Markovic, Bojan.

Afiliação

Tubic B; Department of Pharmaceutical Chemistry, University of Belgrade-Faculty of Pharmacy, Vojvode Stepe 450, 11000 Belgrade, Serbia.
Dobricic V; Department of Pharmaceutical Chemistry, University of Belgrade-Faculty of Pharmacy, Vojvode Stepe 450, 11000 Belgrade, Serbia. Electronic address: vladimir@pharmacy.bg.ac.rs.
Poljarevic J; Department of General and Inorganic Chemistry, University of Belgrade - Faculty of Chemistry, Studentski trg 12-16, 11158 Belgrade, Serbia.
Savic A; Department of General and Inorganic Chemistry, University of Belgrade - Faculty of Chemistry, Studentski trg 12-16, 11158 Belgrade, Serbia.
Sabo T; Department of General and Inorganic Chemistry, University of Belgrade - Faculty of Chemistry, Studentski trg 12-16, 11158 Belgrade, Serbia.
Markovic B; Department of Pharmaceutical Chemistry, University of Belgrade-Faculty of Pharmacy, Vojvode Stepe 450, 11000 Belgrade, Serbia.

J Pharm Biomed Anal ; 184: 113213, 2020 May 30.

Article em En | MEDLINE | ID: mdl-32126457

Assuntos

Nucleotídeos de Desoxicitosina/química; Nucleotídeos de Desoxicitosina/metabolismo; Absorção Gastrointestinal/fisiologia; Absorção Intestinal/fisiologia; Membranas/metabolismo; Pirrolidinonas/química; Pirrolidinonas/metabolismo; Ésteres/química; Ésteres/metabolismo; Humanos; Lecitinas/química; Lecitinas/metabolismo; Membranas Artificiais; Permeabilidade

Palavras-chave

(S,S)-ethylenediamine-N,N'-di-2-(3-cyclohexyl)propanoic acid and (S,S)-1,3-propanediamine-N,N'-di-2-(3-cyclohexyl)propanoic acid derivatives; Membrane permeability; Membrane retention; PAMPA

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Pirrolidinonas / Nucleotídeos de Desoxicitosina / Absorção Gastrointestinal / Absorção Intestinal / Membranas Limite: Humans Idioma: En Ano de publicação: 2020 Tipo de documento: Article

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