Regulation of B cell receptor-dependent NF-&#954;B signaling by the tumor suppressor KLHL14.

Choi, Jaewoo; Phelan, James D; Wright, George W; Häupl, Björn; Huang, Da Wei; Shaffer, Arthur L; Young, Ryan M; Wang, Zhuo; Zhao, Hong; Yu, Xin; Oellerich, Thomas; Staudt, Louis M

Regulation of B cell receptor-dependent NF-κB signaling by the tumor suppressor KLHL14.

Choi, Jaewoo; Phelan, James D; Wright, George W; Häupl, Björn; Huang, Da Wei; Shaffer, Arthur L; Young, Ryan M; Wang, Zhuo; Zhao, Hong; Yu, Xin; Oellerich, Thomas; Staudt, Louis M.

Afiliação

Choi J; Lymphoid Malignancies Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892.
Phelan JD; Lymphoid Malignancies Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892.
Wright GW; Biometric Research Branch, Division of Cancer Diagnosis and Treatment, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892.
Häupl B; Department of Medicine II, Hematology/Oncology, Goethe University, 60590 Frankfurt, Germany.
Huang DW; German Cancer Consortium/German Cancer Research Center, 69120 Heidelberg, Germany.
Shaffer AL; Department of Molecular Diagnostics and Translational Proteomics, Frankfurt Cancer Institute, 60596 Frankfurt, Germany.
Young RM; Lymphoid Malignancies Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892.
Wang Z; Lymphoid Malignancies Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892.
Zhao H; Lymphoid Malignancies Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892.
Yu X; Lymphoid Malignancies Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892.
Oellerich T; Lymphoid Malignancies Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892.
Staudt LM; Lymphoid Malignancies Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892.

Proc Natl Acad Sci U S A ; 117(11): 6092-6102, 2020 03 17.

Article em En | MEDLINE | ID: mdl-32127472

Assuntos

Proteínas de Transporte/genética; Genes Supressores de Tumor; Linfoma Difuso de Grandes Células B/genética; Receptores de Antígenos de Linfócitos B/metabolismo; Complexos Ubiquitina-Proteína Ligase/metabolismo; Adenina/análogos & derivados; Antígenos CD79/genética; Proteínas de Transporte/metabolismo; Linhagem Celular Tumoral; Resistencia a Medicamentos Antineoplásicos/genética; Retículo Endoplasmático/metabolismo; Células HEK293; Humanos; Peptídeos e Proteínas de Sinalização Intracelular; Linfoma Difuso de Grandes Células B/patologia; Mutagênese Sítio-Dirigida; Fator 88 de Diferenciação Mieloide/metabolismo; NF-kappa B/metabolismo; Piperidinas; Proteólise; Pirazóis/farmacologia; Pirazóis/uso terapêutico; Pirimidinas/farmacologia; Pirimidinas/uso terapêutico; Transdução de Sinais/efeitos dos fármacos; Transdução de Sinais/genética

Palavras-chave

B cell receptor; DLBCL; KLHL14; NF-κB

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Receptores de Antígenos de Linfócitos B / Proteínas de Transporte / Genes Supressores de Tumor / Linfoma Difuso de Grandes Células B / Complexos Ubiquitina-Proteína Ligase Tipo de estudo: Prognostic_studies Limite: Humans Idioma: En Ano de publicação: 2020 Tipo de documento: Article

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