Your browser doesn't support javascript.
loading
Magnificamide Is a New Effective Mammalian α-Amylase Inhibitor.
Sintsova, O V; Leychenko, E V; Gladkikh, I N; Kalinovskii, A P; Monastyrnaya, M M; Kozlovskaya, E P.
Afiliação
  • Sintsova OV; Elyakov Pacific Institute of Bioorganic Chemistry, Far Eastern Branch, Russian Academy of Sciences, 690022, Vladivostok, Russia. sintsova0@gmail.com.
  • Leychenko EV; Elyakov Pacific Institute of Bioorganic Chemistry, Far Eastern Branch, Russian Academy of Sciences, 690022, Vladivostok, Russia.
  • Gladkikh IN; Elyakov Pacific Institute of Bioorganic Chemistry, Far Eastern Branch, Russian Academy of Sciences, 690022, Vladivostok, Russia.
  • Kalinovskii AP; Elyakov Pacific Institute of Bioorganic Chemistry, Far Eastern Branch, Russian Academy of Sciences, 690022, Vladivostok, Russia.
  • Monastyrnaya MM; School of Natural Sciences, Far Eastern Federal University, 690091, Vladivostok, Russia.
  • Kozlovskaya EP; Elyakov Pacific Institute of Bioorganic Chemistry, Far Eastern Branch, Russian Academy of Sciences, 690022, Vladivostok, Russia.
Dokl Biochem Biophys ; 489(1): 385-387, 2019 Nov.
Article em En | MEDLINE | ID: mdl-32130606
Recombinant analogue of the sea anemone Heteractismagnifica peptide was obtained, and the kinetic parameters of its interaction with mammalian α-amylases were determined. Magnificamide inhibits α-amylases significantly stronger than the medical drug acarbose (PrecoseTM or GlucobayTM). Magnificamide is assumed to find application as a drug for prevention and treatment of metabolic disorders and type 2 diabetes mellitus.
Assuntos
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Peptídeos / Inibidores Enzimáticos / Alfa-Amilases Limite: Animals Idioma: En Ano de publicação: 2019 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Peptídeos / Inibidores Enzimáticos / Alfa-Amilases Limite: Animals Idioma: En Ano de publicação: 2019 Tipo de documento: Article