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Early detection of diabetic kidney disease by urinary proteomics and subsequent intervention with spironolactone to delay progression (PRIORITY): a prospective observational study and embedded randomised placebo-controlled trial.
Tofte, Nete; Lindhardt, Morten; Adamova, Katarina; Bakker, Stephan J L; Beige, Joachim; Beulens, Joline W J; Birkenfeld, Andreas L; Currie, Gemma; Delles, Christian; Dimos, Ingo; Francová, Lidmila; Frimodt-Møller, Marie; Girman, Peter; Göke, Rüdiger; Havrdova, Tereza; Heerspink, Hiddo J L; Kooy, Adriaan; Laverman, Gozewijn D; Mischak, Harald; Navis, Gerjan; Nijpels, Giel; Noutsou, Marina; Ortiz, Alberto; Parvanova, Aneliya; Persson, Frederik; Petrie, John R; Ruggenenti, Piero L; Rutters, Femke; Rychlík, Ivan; Siwy, Justyna; Spasovski, Goce; Speeckaert, Marijn; Trillini, Matias; Zürbig, Petra; von der Leyen, Heiko; Rossing, Peter.
Afiliação
  • Tofte N; Steno Diabetes Center Copenhagen, Gentofte, Denmark.
  • Lindhardt M; Steno Diabetes Center Copenhagen, Gentofte, Denmark.
  • Adamova K; University Clinic of Endocrinology, Diabetes and Metabolic Disorders, Skopje, Macedonia.
  • Bakker SJL; Division of Nephrology, Department of Internal Medicine, University Medical Center Groningen, University of Groningen, Groningen, Netherlands.
  • Beige J; Division of Nephrology and KfH Renal Unit, Hospital St Georg, Leipzig, Germany; Martin-Luther University Halle, Wittenberg, Germany.
  • Beulens JWJ; Amsterdam Public Health Research Institute, VU University Medical Center, Amsterdam, Netherlands; Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, Netherlands.
  • Birkenfeld AL; Department of Internal Medicine IV, Division of Endocrinology, Diabetology, and Nephrology, University Hospital Tübingen, Tübingen, Germany; Institute for Diabetes Research and Metabolic Diseases, Helmholtz Center Munich at Eberhard Karls University of Tübingen, Tübingen, Germany; German Center for
  • Currie G; Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, UK.
  • Delles C; Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, UK.
  • Dimos I; Diabetespraxis, Leipzig, Germany.
  • Francová L; 1st Department, Charles University, Third Faculty of Medicine, Prague, Czech Republic.
  • Frimodt-Møller M; Steno Diabetes Center Copenhagen, Gentofte, Denmark.
  • Girman P; Diabetes Center, Institute for Clinical and Experimental Medicine, Prague, Czech Republic.
  • Göke R; Diabetologische Schwerpunktpraxis, Diabetologen Hessen, Marburg, Germany.
  • Havrdova T; Diabetes Center, Institute for Clinical and Experimental Medicine, Prague, Czech Republic.
  • Heerspink HJL; Department of Clinical Pharmacy and Pharmacology, University Medical Center Groningen, University of Groningen, Groningen, Netherlands.
  • Kooy A; Bethesda Diabetes Research Center, Hoogeveen, Netherlands; Diabetes Vascular Research Foundation (DVRF), Hoogeveen, Netherlands; University Medical Center Groningen, Groningen, Netherlands.
  • Laverman GD; Department of Internal Medicine/Nephrology, Ziekenhuisgroep Twente Hospital, Almelo, Netherlands.
  • Mischak H; Mosaiques Diagnostics, Hannover, Germany.
  • Navis G; Division of Nephrology, Department of Internal Medicine, University Medical Center Groningen, University of Groningen, Groningen, Netherlands.
  • Nijpels G; Department General Practice and Elderly Care, Amsterdam, Netherlands.
  • Noutsou M; Diabetes Center, 2nd Department of Internal Medicine, Medical School, National and Kapodistrian University of Athens, Hippokratio General Hospital, Athens, Greece.
  • Ortiz A; Instituto de Investigacion Sanitaria de la Fundacion Jiménez Díaz UAM, Madrid, Spain.
  • Parvanova A; Department of Renal Medicine, Clinical Research Centre for Rare Diseases "Aldo e CeleDaccò": Istituto di Ricerche Farmacologiche Mario Negri IRCCS, Ranica, Bergamo, Italy.
  • Persson F; Steno Diabetes Center Copenhagen, Gentofte, Denmark.
  • Petrie JR; Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, UK.
  • Ruggenenti PL; Department of Renal Medicine, Clinical Research Centre for Rare Diseases "Aldo e CeleDaccò": Istituto di Ricerche Farmacologiche Mario Negri IRCCS, Ranica, Bergamo, Italy.
  • Rutters F; Amsterdam Public Health Research Institute, VU University Medical Center, Amsterdam, Netherlands.
  • Rychlík I; 1st Department, Charles University, Third Faculty of Medicine, Prague, Czech Republic; Faculty Hospital Královské Vinohrady, Prague, Czech Republic.
  • Siwy J; Mosaiques Diagnostics, Hannover, Germany.
  • Spasovski G; Department of Nephrology, Cyril and Methodius University in Skopje, Skopje, North Macedonia.
  • Speeckaert M; Department of Nephrology, Ghent University Hospital, Ghent, Belgium.
  • Trillini M; Department of Renal Medicine, Clinical Research Centre for Rare Diseases "Aldo e CeleDaccò": Istituto di Ricerche Farmacologiche Mario Negri IRCCS, Ranica, Bergamo, Italy.
  • Zürbig P; Mosaiques Diagnostics, Hannover, Germany.
  • von der Leyen H; Hannover Clinical Trial Center, Hannover Medical School, Hannover, Germany.
  • Rossing P; Steno Diabetes Center Copenhagen, Gentofte, Denmark; University of Copenhagen, Copenhagen, Denmark. Electronic address: peter.rossing@regionh.dk.
Lancet Diabetes Endocrinol ; 8(4): 301-312, 2020 04.
Article em En | MEDLINE | ID: mdl-32135136
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Espironolactona / Diabetes Mellitus Tipo 2 / Nefropatias Diabéticas / Antagonistas de Receptores de Mineralocorticoides Tipo de estudo: Clinical_trials / Diagnostic_studies / Observational_studies / Risk_factors_studies / Screening_studies Limite: Adult / Aged / Female / Humans / Male / Middle aged Idioma: En Ano de publicação: 2020 Tipo de documento: Article
Texto completo
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Espironolactona / Diabetes Mellitus Tipo 2 / Nefropatias Diabéticas / Antagonistas de Receptores de Mineralocorticoides Tipo de estudo: Clinical_trials / Diagnostic_studies / Observational_studies / Risk_factors_studies / Screening_studies Limite: Adult / Aged / Female / Humans / Male / Middle aged Idioma: En Ano de publicação: 2020 Tipo de documento: Article