Relayed Proton Brake in N-Pyridyl-2-iso-propylaniline Derivative: Two Brakes with One Proton.
J Org Chem
; 85(7): 5109-5113, 2020 Apr 03.
Article
em En
| MEDLINE
| ID: mdl-32138515
ABSTRACT
The addition of methanesulfonic acid to N-(2,6-dimethylpyridin-4-yl)-N-methyl-2-iso-propylaniline led to the selective protonation of the pyridine nitrogen atom, resulting in a significant deceleration of the rotation rates around both N-pyridyl and N-(i-Pr)phenyl bonds through a relayed brake mechanism.
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MEDLINE
Idioma:
En
Ano de publicação:
2020
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Article