Assessment of the inhibition risk of paris saponins, bioactive compounds from Paris polyphylla, on CYP and UGT enzymes via cocktail inhibition assays.

Luo, Han; Xu, Yuan; Sun, Dongyi; Cheng, Yi; Sun, Zhenliang; Gao, Jing; Zhang, Yuanjin; Wang, Xin

Luo, Han; Xu, Yuan; Sun, Dongyi; Cheng, Yi; Sun, Zhenliang; Gao, Jing; Zhang, Yuanjin; Wang, Xin.

Afiliação

Luo H; Shanghai Key Laboratory of Regulatory Biology, Institute of Biomedical Sciences and School of Life Sciences, East China Normal University, Shanghai, China.
Xu Y; Shanghai Key Laboratory of Regulatory Biology, Institute of Biomedical Sciences and School of Life Sciences, East China Normal University, Shanghai, China.
Sun D; Shanghai Key Laboratory of Regulatory Biology, Institute of Biomedical Sciences and School of Life Sciences, East China Normal University, Shanghai, China.
Cheng Y; Shanghai Key Laboratory of Regulatory Biology, Institute of Biomedical Sciences and School of Life Sciences, East China Normal University, Shanghai, China.
Sun Z; Southern Medical University Affiliated Fengxian Hospital, Shanghai, China. Electronic address: zhenliang6@126.com.
Gao J; College of Life Sciences, Northwest University, Xi'an, China.
Zhang Y; Shanghai Key Laboratory of Regulatory Biology, Institute of Biomedical Sciences and School of Life Sciences, East China Normal University, Shanghai, China.
Wang X; Shanghai Key Laboratory of Regulatory Biology, Institute of Biomedical Sciences and School of Life Sciences, East China Normal University, Shanghai, China. Electronic address: xwang@bio.ecnu.edu.cn.

Regul Toxicol Pharmacol ; 113: 104637, 2020 Jun.

Article em En | MEDLINE | ID: mdl-32145316

Assuntos

Sistema Enzimático do Citocromo P-450/metabolismo; Inibidores Enzimáticos/farmacologia; Glucuronosiltransferase/antagonistas & inibidores; Microssomos Hepáticos/efeitos dos fármacos; Saponinas/farmacologia; Animais; Relação Dose-Resposta a Droga; Inibidores Enzimáticos/química; Glucuronosiltransferase/metabolismo; Humanos; Masculino; Microssomos Hepáticos/enzimologia; Conformação Molecular; Ratos; Ratos Sprague-Dawley; Medição de Risco; Saponinas/química; Estereoisomerismo; Relação Estrutura-Atividade

Palavras-chave

Cytochrome P450 (CYP); Paris saponins; Polyphyllin; Risk evaluation; UDP-Glucuronosyltransferases (UGT)

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Saponinas / Microssomos Hepáticos / Glucuronosiltransferase / Sistema Enzimático do Citocromo P-450 / Inibidores Enzimáticos Tipo de estudo: Etiology_studies / Risk_factors_studies Limite: Animals / Humans / Male Idioma: En Ano de publicação: 2020 Tipo de documento: Article

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